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INVITED REVIEW

Regulation of TRPV5 and TRPV6 by associated proteins

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

The epithelial Ca²⁺ channels TRPV5 and TRPV6 are the most Ca²⁺-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca²⁺ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca²⁺ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes.

Rab11; calbindin; 80KH; BSPRY; Klotho; kidney

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