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Am J Physiol Renal Physiol 290: F1295-F1302, 2006; doi:10.1152/ajprenal.00443.2005
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INVITED REVIEW

Regulation of TRPV5 and TRPV6 by associated proteins

Stan F. J. van de Graaf, Joost G. J. Hoenderop, and René J. M. Bindels

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes.

Rab11; calbindin; 80KH; BSPRY; Klotho; kidney



Address for reprint requests and other correspondence: R. Bindels, 286 Physiology, Radboud Univ. Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands (e-mail: r.bindels{at}ncmls.ru.nl)




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