HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Am J Physiol Renal Physiol 292: F423-F429, 2007. First published August 29, 2006; doi:10.1152/ajprenal.00124.2006
0363-6127/07 $8.00

This Article Free upon publication Full Text Full Text (PDF) All Versions of this Article: 292/1/F423    most recent 00124.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Sánchez-Lozada, L. G. Articles by Franco, M. Search for Related Content PubMed PubMed Citation Articles by Sánchez-Lozada, L. G. Articles by Franco, M.

Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats

Laura G. Sánchez-Lozada,¹ Edilia Tapia,¹ Adriana Jiménez,¹ Pablo Bautista,¹ Magdalena Cristóbal,¹ Tomás Nepomuceno,¹ Virgilia Soto,² Carmen Ávila-Casado,² Takahiko Nakagawa,³ Richard J. Johnson,³ Jaime Herrera-Acosta,^1, and Martha Franco¹

Departments of ¹Nephrology and ²Pathology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; and ³Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida

Submitted 13 April 2006 ; accepted in final form 23 August 2006

Fructose intake has been recently linked to the epidemic of metabolic syndrome and, in turn, the metabolic syndrome has been epidemiologically linked with renal progression. The renal hemodynamic effects of fructose intake are unknown, as well as the effects of different routes of administration. Metabolic syndrome was induced in rats over 8 wk by either a high-fructose diet (60%, F60, n = 7) or by adding fructose to drinking water (10%, F10, n = 7). Body weight and food and fluid intake of each rat were measured weekly during the follow-up. At baseline and at the end of wk 8, systolic blood pressure, plasma uric acid, and triglycerides were measured. At the end of week 8 glomerular hemodynamics was evaluated by micropuncture techniques. Wall thickening in outer cortical and juxtamedullary afferent arterioles was assessed by immunohistochemistry and computer image analysis. Fructose administration either in diet or drinking water induced hypertension, hyperuricemia, and hypertriglyceridemia; however, there was a progressive increment in these parameters with higher fructose intake (C<F10<F60). In addition, the F60 rats developed kidney hypertrophy, glomerular hypertension, cortical vasoconstriction, and arteriolopathy of preglomerular vessels. In conclusion, fructose-induced metabolic syndrome is associated with renal disturbances characterized by renal hypertrophy, arteriolopathy, glomerular hypertension, and cortical vasoconstriction. These changes are best observed in rats administered high doses (60% diet) of fructose.

uric acid; obesity

This article has been cited by other articles:

				L. G. Sanchez-Lozada, E. Tapia, P. Bautista-Garcia, V. Soto, C. Avila-Casado, I. P. Vega-Campos, T. Nakagawa, L. Zhao, M. Franco, and R. J. Johnson Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome Am J Physiol Renal Physiol, April 1, 2008; 294(4): F710 - F718. [Abstract] [Full Text] [PDF]

				C. M. Brown, A. G. Dulloo, G. Yepuri, and J.-P. Montani Fructose ingestion acutely elevates blood pressure in healthy young humans Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R730 - R737. [Abstract] [Full Text] [PDF]

				R. J Johnson, M. S Segal, Y. Sautin, T. Nakagawa, D. I Feig, D.-H. Kang, M. S Gersch, S. Benner, and L. G Sanchez-Lozada Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease Am. J. Clinical Nutrition, October 1, 2007; 86(4): 899 - 906. [Abstract] [Full Text] [PDF]

				E. G. Neilson The Fructose Nation J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2619 - 2621. [Full Text] [PDF]

				M. S. Gersch, W. Mu, P. Cirillo, S. Reungjui, L. Zhang, C. Roncal, Y. Y. Sautin, R. J. Johnson, and T. Nakagawa Fructose, but not dextrose, accelerates the progression of chronic kidney disease Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1256 - F1261. [Abstract] [Full Text] [PDF]

				C. Roncal, W. Mu, S. Reungjui, K. M. Kim, G. N. Henderson, X. Ouyang, T. Nakagawa, and R. J. Johnson Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1391 - F1396. [Abstract] [Full Text] [PDF]

				D. J. Chess, B. Lei, B. D. Hoit, A. M. Azimzadeh, and W. C. Stanley Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1853 - H1860. [Abstract] [Full Text] [PDF]

				X. Gao, L. Qi, N. Qiao, H. K. Choi, G. Curhan, K. L. Tucker, and A. Ascherio Intake of Added Sugar and Sugar-Sweetened Drink and Serum Uric Acid Concentration in US Men and Women Hypertension, August 1, 2007; 50(2): 306 - 312. [Abstract] [Full Text] [PDF]