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This Article Full Text Full Text (PDF) All Versions of this Article: 292/2/F895    most recent 00219.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Chakraborty, A. Articles by Sheikh-Hamad, D. Search for Related Content PubMed PubMed Citation Articles by Chakraborty, A. Articles by Sheikh-Hamad, D.

Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes

³Renal Section, Department of Medicine, and ¹Leukocyte Biology, Children's Nutritional Research Center, Baylor College of Medicine, ⁴Department of Pathology and Laboratory Medicine, University of Texas Health Sciences Center, and ⁵Department of Renal Pathology, Methodist Hospital, Houston, Texas; and ²Department of Physiology, University of Arizona, Tucson, Arizona

Submitted 14 June 2006 ; accepted in final form 3 October 2006

The mammalian counterpart of the fish calcium-regulating hormone stanniocalcin-1 (STC1) inhibits monocyte chemotactic protein-1- and stromal-derived factor-1 (SDF-1)-mediated chemotaxis and diminishes chemokinesis in macrophage-like RAW264.7 and U937 cells in a manner that may involve attenuation of the intracellular calcium signal. STC1 is strongly induced in the kidney following obstructive injury. We hypothesized that STC1 may serve to attenuate the influx of inflammatory cells to the site of tissue injury. In this study, we examined the effect of STC1 on the migration of freshly isolated human macrophages, neutrophils, and T and B lymphocytes through quiescent or IL-1-treated human umbilical vein endothelial cell (HUVEC) monolayers. STC1 inhibited transmigration of macrophages and T lymphocytes through quiescent or IL-1-activated HUVECs but did not attenuate the transmigration of neutrophils and B lymphocytes. STC1 regulates gene expression in cultured endothelial cells and is detected on the apical surface of endothelial cells in vivo. The data suggest that STC1 plays a critical role in transendothelial migration of inflammatory cells and is involved in the regulation of numerous aspects of endothelial function.

array; inflammation; vascular biology; calcium regulation

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