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This Article Full Text Full Text (PDF) All Versions of this Article: 292/6/F1726    most recent 00436.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Leong, C.-L. Articles by Evans, R. G. Search for Related Content PubMed PubMed Citation Articles by Leong, C.-L. Articles by Evans, R. G.

Evidence that renal arterial-venous oxygen shunting contributes to dynamic regulation of renal oxygenation

¹Department of Physiology, Monash University, Melbourne, Australia; and ²Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin

Submitted 2 November 2006 ; accepted in final form 20 February 2007

Renal blood flow (RBF) can be reduced in rats and rabbits by up to 40% without significant changes in renal tissue PO₂. We determined whether this occurs because renal oxygen consumption changes with RBF or due to some other mechanism. The relationships between RBF and renal cortical and medullary tissue PO₂ and renal oxygen metabolism were determined in the denervated kidneys of anesthetized rabbits under hypoxic, normoxic, and hyperoxic conditions. During artificial ventilation with 21% oxygen (normoxia), RBF increased 32 ± 8% during renal arterial infusion of acetylcholine and reduced 31 ± 5% during ANG II infusion. Neither infusion significantly altered arterial pressure, tissue PO₂ in the renal cortex or medulla, nor renal oxygen consumption. However, fractional oxygen extraction fell as RBF increased and the ratio of oxygen consumption to sodium reabsorption increased during ANG II infusion. Ventilation with 10% oxygen (hypoxia) significantly reduced both cortical and medullary PO₂ (60–70%), whereas ventilation with 50% and 100% oxygen (hyperoxia) increased cortical and medullary PO₂ (by 62–298 and 30–56%, respectively). However, responses to altered RBF under hypoxic and hyperoxic conditions were similar to those under normoxic conditions. Thus renal tissue PO₂ was relatively independent of RBF within a physiological range (±30%). This was not due to RBF-dependent changes in renal oxygen consumption. The observation that fractional extraction of oxygen fell with increased RBF, yet renal parenchymal PO₂ remained unchanged, supports the hypothesis that preglomerular diffusional shunting of oxygen from arteries to veins increases with increasing RBF, and so contributes to dynamic regulation of intrarenal oxygenation.

arteriovenous shunt; diffusional shunt; hypoxia; ischemia

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