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This Article Full Text Full Text (PDF) All Versions of this Article: 293/5/F1691    most recent 00235.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Cruz, C. Articles by Pedraza-Chaverri, J. Search for Related Content PubMed PubMed Citation Articles by Cruz, C. Articles by Pedraza-Chaverri, J.

Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats

¹Departamento de Nefrología y Metabolismo Mineral and ³Departamento de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; ²Departamento de Biología Celular, Escuela Médico Militar, Universidad del Ejército y Fuerza Aérea; ⁴Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez; ⁵Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México; and ⁶Departamento de Nefrología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

Submitted 18 May 2007 ; accepted in final form 6 August 2007

Progressive renal damage and hypertension are associated with oxidative and nitrosative stress. On the other hand, S-allylcysteine (SAC), the most abundant organosulfur compound in aged garlic extract (AG), has antioxidant properties. The effects of SAC and AG on blood pressure, renal damage, and oxidative and nitrosative stress were studied in five-sixths nephrectomized rats treated with SAC (200 mg/kg ip) and AG (1.2 ml/kg ip) every other day for 30 days. Proteinuria and serum creatinine and blood urea nitrogen concentrations were measured on days 0, 5, 10, 15, and 30, and systolic blood pressure was recorded on days 0, 15, and 30. The degree of glomerulosclerosis and tubulointerstitial damage, the immunostaining for inducible nitric oxide synthase, 3-nitrotyrosine, poly(ADP-ribose), and the subunits of NADPH oxidase p22^phox and gp91^phox, and the activity of SOD were determined on day 30. SAC and AG reduced hypertension, renal damage, and the abundance of inducible nitric oxide synthase, 3-nitrotyrosine, poly(ADP-ribose), p22^phox, and gp91^phox and increased SOD activity. Our data suggest that the antihypertensive and renoprotective effects of SAC and AG are associated with their antioxidant properties and that they may be used to ameliorate hypertension and delay the progression of renal damage.

aged garlic; renal injury; hypertension; superoxide anion