HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 293/6/F1761    most recent 00400.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Huang, C.-L. Search for Related Content PubMed PubMed Citation Articles by Huang, C.-L.

INVITED REVIEW

Complex roles of PIP₂ in the regulation of ion channels and transporters

Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

Submitted 29 August 2007 ; accepted in final form 3 October 2007

The regulation of ion channels and transporters by phosphoinositides has received much attention over the past 10 years. There are multiple potential mechanisms for regulation of ion channels and transporters by PIP₂, including a direct binding of PIP₂ to the target proteins, alterations of membrane insertion, and retrieval. Added to the complexities of multiple potential mechanisms is how cells use PIP₂ to regulate so many different processes. Here, I briefly review several past and recent studies to illustrate the complexities and raise outstanding questions for future studies.

endocytosis; exocytosis; phosphoinositide; PIP5K; Arf; Rho