AJP - Renal AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 294: F614-F620, 2008. First published January 16, 2008; doi:10.1152/ajprenal.00470.2007
0363-6127/08 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
294/3/F614    most recent
00470.2007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hladunewich, M. A.
Right arrow Articles by Lafayette, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hladunewich, M. A.
Right arrow Articles by Lafayette, R. A.

Course of preeclamptic glomerular injury after delivery

M. A. Hladunewich,1 B. D. Myers,2 G. C. Derby,2 K. L. Blouch,2 M. L. Druzin,3 W. M. Deen,4 D. M. Naimark,1 and R. A. Lafayette2

1Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; 2Division of Nephrology, Department of Medicine and 3Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California; and 4Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts

Submitted 9 October 2007 ; accepted in final form 6 January 2008

We evaluated the early postpartum recovery of glomerular function over 4 wk in 57 women with preeclampsia. We used physiological techniques to measure glomerular filtration rate (GFR), renal plasma flow, and oncotic pressure ({pi}A) and computed a value for the two-kidney ultrafiltration coefficient (Kf). Compared with healthy, postpartum controls, GFR was depressed by 40% on postpartum day 1, but by only 19% and 8% in the second and fourth postpartum weeks, respectively. Hypofiltration was attributable solely to depression, at corresponding postpartum times, of Kf by 55%, 30%, and 18%, respectively. Improvement in glomerular filtration capacity was accompanied by recovery of hypertension to near-normal levels and significant improvement in albuminuria. We conclude that the functional manifestations of the glomerular endothelial injury of preeclampsia largely resolve within the first postpartum month.

glomerular filtration rate; ultrafiltration coefficient; postpartum recovery


Address for reprint requests and other correspondence: M. A. Hladunewich, Divisions of Nephrology and Critical Care, Dept. of Medicine, Rm. A240, Sunnybrook Health Sciences Center A139, 2075 Bayview Ave., Toronto, ON, Canada M4N 3M5 (e-mail: michelle.hladunewich{at}sunnybrook.ca)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2008 by the American Physiological Society.