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This Article Full Text Full Text (PDF) All Versions of this Article: 296/2/F306    most recent 90326.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Garman, J. H. Articles by Maric, C. Search for Related Content PubMed PubMed Citation Articles by Garman, J. H. Articles by Maric, C.

Omega-3 fatty acid rich diet prevents diabetic renal disease

Departments of ¹Physiology and Biophysics and ²Medicine, Georgetown University Medical Center, Washington, District of Columbia; and ³Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi

Submitted 21 May 2008 ; accepted in final form 1 December 2008

Omega-3 polyunsaturated fatty acids (n-3 PUFA) show beneficial effects in cardiovascular disease, IgA, and diabetic nephropathy; however, the mechanisms underlying these benefits are unknown. The study was performed in male Sprague-Dawley rats randomly divided into four treatment groups: nondiabetic (ND), streptozotocin-induced diabetic (D), diabetic and fed a high n-3 PUFA diet (D+canola), and diabetic and fed a high n-6 (omega-6) PUFA diet (D+corn). Study treatments were carried out for 30 wk. D+canola significantly decreased diabetes-associated increases in urine albumin excretion (ND 17.8 ± 6.4; D 97.3 ± 9.4; D+canola 8.3 ± 2.2 mg/day); systolic blood pressure (ND 153 ± 9; D 198 ± 7; D+canola 162 ± 9 mmHg); glomerulosclerosis (ND 0.6 ± 0.2; D 1.8 ± 0.2; D+canola 0.8 ± 0.1 AU); and tubulointerstitial fibrosis in the renal cortex (ND 1.2 ± 0.2; D 2.0 ± 0.2; D+canola 1.1 ± 0.1) and the inner stripe of the outer medulla (ND 1.0 ± 0.2; D 2.1 ± 0.2; D+canola 1.1 ± 0.2 AU). D+corn also exerted renoprotection, but not to the same degree as D+canola (urine albumin excretion, 33.8 ± 6.1 mg/day; systolic blood pressure, D+corn 177 ± 6 mmHg; glomerulosclerosis, D+corn 1.2 ± 0.3 AU; cortical tubulointerstitial fibrosis, D+corn 1.6 ± 0.1 AU; medullary tubulointerstitial fibrosis, D+corn 1.5 ± 0.1 AU). In addition, D+canola attenuated D-associated increase in collagen type I and type IV, IL-6, MCP-1, transforming growth factor-β, and CD68 expression. These observations indicate a beneficial effect of high dietary intake of n-3 PUFA in reducing diabetic renal disease.

diabetes; kidney; omega-3; PUFA; glomerulosclerosis; tubulointerstitial fibrosis; hypertension; canola