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Am J Physiol Renal Physiol 296: F669-F679, 2009. First published November 19, 2008; doi:10.1152/ajprenal.90513.2008
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REVIEW

Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury

Eisei Noiri,1 Kent Doi,1 Kousuke Negishi,1 Tamami Tanaka,1 Yoshifumi Hamasaki,1 Toshiro Fujita,1 Didier Portilla,2 and Takeshi Sugaya3

1Department of Nephrology and Endocrinology and Department of Hemodialysis and Apheresis, University Hospital, University of Tokyo, Tokyo, Japan; 2Division of Nephrology, Departments of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas; and 3CMIC Company, Limited, Tokyo, Japan

Submitted 26 August 2008 ; accepted in final form 18 November 2008

ABSTRACT

In the development of novel therapeutic strategies for kidney disease, new renal biomarkers for early detection and accurate evaluation of renal injury are urgently required for both acute kidney injury (AKI) and chronic kidney disease (CKD). Fatty acid-binding protein 1 (FABP1) is expressed in renal proximal tubule cells and shed into urine in response to hypoxia caused by decreased peritubular capillary blood flow. To clarify the role of urinary FABP1 in kidney disease, we established human FABP1 transgenic mice and evaluated the responses of FABP1 to several AKI and CKD models. Moreover, there are accumulating clinical data that urinary FABP1 can detect human AKI earlier than serum creatinine and can distinguish the risk population for AKI. Investigation with "humanized" FABP1 transgenic mice and measurement of clinical samples allowed us to develop urinary FABP1 as a new renal biomarker. Further clinical studies are necessary to confirm the potential of urinary FABP1 for clinical application.

acute kidney injury; chronic kidney disease; tubular injury; hypoxia


Address for reprint requests and other correspondence: E. Noiri, 107 Lab., Depts. of Nephrology and Endocrinology, Univ. of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, Japan 113-8655 (e-mail: noiri-tky{at}umin.ac.jp)






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