HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 296/5/F1006    most recent 90448.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Neubauer, B. Articles by Wagner, C. Search for Related Content PubMed PubMed Citation Articles by Neubauer, B. Articles by Wagner, C.

Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway

¹Department of Physiology, Universität Regensburg, Regensburg, Germany; ²National Institutes of Health, Bethesda, Maryland; ³Department of Pediatrics, Faculty of Medicine, University of Regensburg, Regensburg, Germany; and ⁴University of Virginia, Charlottesville, Virginia

Submitted 30 July 2008 ; accepted in final form 3 March 2009

During metanephric kidney development, renin expression in the renal vasculature begins in larger vessels, shifting to smaller vessels and finally remaining restricted to the terminal portions of afferent arterioles at the entrance into the glomerular capillary network. The mechanisms determining the successive expression of renin along the vascular axis of the kidney are not well understood. Since the cAMP signaling cascade plays a central role in the regulation of both renin secretion and synthesis in the adult kidney, it seemed feasible that this pathway might also be critical for renin expression during kidney development. In the present study we determined the spatiotemporal development of renin expression and the development of the preglomerular arterial tree in mouse kidneys with renin cell-specific deletion of G_s, a core element for receptor activation of adenylyl cyclases. We found that in the absence of the G_s protein, renin expression was largely absent in the kidneys at any developmental stage, accompanied by alterations in the development of the preglomerular arterial tree. These data indicate that the maintenance of renin expression following a specific spatiotemporal pattern along the preglomerular vasculature critically depends on the availability of G_s. We infer from our data that the cAMP signaling pathway is not only critical for the regulation of renin synthesis and secretion in the mature kidney but that it also is critical for establishing the juxtaglomerular expression site of renin during development.

fetal kidney; transgenic mice

This article has been cited by other articles:

				K. Machura, D. Steppan, B. Neubauer, N. Alenina, T. M. Coffman, C. S. Facemire, K. F. Hilgers, K.-U. Eckardt, C. Wagner, and A. Kurtz Developmental renin expression in mice with a defective renin-angiotensin system Am J Physiol Renal Physiol, November 1, 2009; 297(5): F1371 - F1380. [Abstract] [Full Text] [PDF]