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This Article Full Text Full Text (PDF) All Versions of this Article: 296/6/F1355    most recent 90622.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Kelly, K. J. Articles by Dominguez, J. H. PubMed PubMed Citation Articles by Kelly, K. J. Articles by Dominguez, J. H.

Acute-phase response protein serum amyloid A stimulates renal tubule formation: studies in vitro and in vivo

Departments of ¹Medicine and ²Pathology, Indiana University and the ³Veterans Administration Medical Center, Indianapolis, Indiana

Submitted 20 October 2008 ; accepted in final form 28 March 2009

Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acute-phase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that feature a proximal tubule phenotype. We also found strong SAA expression in states of tubule formation (in utero stage) and regeneration (recovery from ischemia-reperfusion injury). These data lend support to a novel view of a more localized renal acute-phase reaction, where renal SAA may act as a paracrine or autocrine molecule that promotes tubule formation during development and repair.

tubulogenesis; acute kidney injury; kidney development