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This Article Full Text Full Text (PDF) All Versions of this Article: 297/1/F210    most recent 90260.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (2) Google Scholar Articles by Wu, W. Articles by Nigam, S. K. PubMed PubMed Citation Articles by Wu, W. Articles by Nigam, S. K.

β1-Integrin is required for kidney collecting duct morphogenesis and maintenance of renal function

Departments of ¹Pediatrics, ²Medicine, ³Radiology and ⁴Cellular Molecular Medicine, ⁵VA Healthcare San Diego, and the ⁶John and Rebecca Moores UCSD Cancer Center, School of Medicine, University of California, La Jolla, California

Submitted 18 April 2008 ; accepted in final form 8 May 2009

Deletion of integrin-β1 (Itgb1) in the kidney collecting system led to progressive renal dysfunction and polyuria. The defect in the concentrating ability of the kidney was concomitant with decreased medullary collecting duct expression of aquaporin-2 and arginine vasopressin receptor 2, while histological examination revealed hypoplastic renal medullary collecting ducts characterized by increased apoptosis, ectasia and cyst formation. In addition, a range of defects from small kidneys with cysts and dilated tubules to bilateral renal agenesis was observed. This was likely due to altered growth and branching morphogenesis of the ureteric bud (the progenitor tissue of the renal collecting system), despite the apparent ability of the ureteric bud-derived cells to induce differentiation of the metanephric mesenchyme. These data not only support a role for Itgb1 in the development of the renal collecting system but also raise the possibility that Itgb1 links morphogenesis to terminal differentiation and ultimately collecting duct function and/or maintenance.

ureteric bud; metanephric mesenchyme; branching morphogenesis; cystic kidney disease; diabetes insipidus; renal failure; polyuria

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