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Am J Physiol Renal Physiol 297: F553-F558, 2009. First published April 1, 2009; doi:10.1152/ajprenal.00045.2009
0363-6127/09 $8.00
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REVIEW

MicroRNA: a new frontier in kidney and blood pressure research

Mingyu Liang,1 Yong Liu,1 Domagoj Mladinov,1 Allen W. Cowley, Jr.,1 Hariprasad Trivedi,2 Yi Fang,3 Xialian Xu,3 Xiaoqiang Ding,3 and Zhongmin Tian4

1Department of Physiology and 2Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin; 3Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai; and 4Department of Biomedical Engineering, Xi'an Jiaotong University, Shanxi, China

Submitted 27 January 2009 ; accepted in final form 30 March 2009

ABSTRACT

MicroRNA (miRNA) has emerged rapidly as a major new direction in many fields of research including kidney and blood pressure research. A mammalian genome encodes several hundred miRNAs. These miRNAs potentially regulate the expression of thousands of proteins. miRNA expression profiles differ substantially between the kidney and other organs as well as between kidney regions. miRNAs may be functionally important in models of diabetic nephropathy, podocyte development, and polycystic disease. miRNAs may be involved in the regulation of arterial blood pressure, including possible involvement in genetic elements of hypertension. Studies of miRNAs could generate diagnostic biomarkers for kidney disease and new mechanistic insights into the complex regulatory networks underlying kidney disease and hypertension. Further progress in the understanding of miRNA biogenesis and action and technical improvements for target identification and miRNA manipulation will be important for studying miRNAs in renal function and blood pressure regulation.

hypertension; acute kidney injury; chronic kidney disease; gene


Address for reprint requests and other correspondence: M. Liang, Dept. of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226 (e-mail: mliang{at}mcw.edu)




This article has been cited by other articles:


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 Physiol. GenomicsHome page
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MicroRNA: a new entrance to the broad paradigm of systems molecular medicine
Physiol Genomics, July 9, 2009; 38(2): 113 - 115.
[Abstract] [Full Text] [PDF]


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