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Am J Physiol Renal Physiol 297: F1502-F1509, 2009. First published July 22, 2009; doi:10.1152/ajprenal.00130.2009
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REVIEW-ARTICLE

A new role for vitamin D receptor activation in chronic kidney disease

José M. Valdivielso,1 Jorge Cannata-Andía,2 Blai Coll,1 and Elvira Fernández1

1Laboratorio de Nefrología Experimental, Hospital Universitario Arnau de Vilanova, IRBLLEIDA, Red de Investigatión Renal del Instituto de Salud Carlos III (REDinREN ISCIII), Lleida; and ; 2Servicio de Metabolismo Óseo y Mineral, Hospital Universitario Central de Asturias, Instituto Reina Sofía de Investigación, REDinREN ISCIII, Universidad de Oviedo, Oviedo, Spain

Submitted March 5, 2009 ; accepted in final form July 17, 2009

Vitamin D has proven to be much more than a simple "calcium hormone." The fact that the vitamin D receptor has been found in cells not related to mineral metabolism supports that statement. The interest of nephrologists in vitamin D and its effects beyond mineral metabolism has increased over the last few years, evidencing the importance of this so-called "sunshine hormone." In the present review, we highlight the most recent developments in the traditional use of vitamin D in chronic kidney disease (CKD) patients, namely, the control of secondary hyperparathyroidism (sHPT). Furthermore, we also explore the data available regarding the new possible therapeutic uses of vitamin D for the treatment of other complications present in CKD patients, such as vascular calcification, left ventricular hypertrophy, or proteinuria. Finally, some still scarce but very promising data regarding a possible role of vitamin D in kidney transplant patients also are reviewed. The available data point to a potential beneficial effect of vitamin D in CKD patients beyond the control of mineral metabolism.


Address for reprint requests and other correspondence: J. M. Valdivielso, Laboratorio de Nefrología Experimental, IRBLLEIDA, Hospital Universitari Arnau de Vilanova, Rovira Roure 80, 25198 Lleida, Spain (e-mail: valdivielso{at}medicina.udl.es).






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