The Serum and Glucocorticoid regulated Kinase (SGK1) is a component of the pathway mediating activation of the epithelial sodium channel, ENaC, in the aldosterone-sensitive distal nephron (ASDN). Two knockout mouse models for SGK1 have now been described. On a low salt diet salt wasting is observed in both models, but decreased ENaC activity is reported in the collecting ducts of one model while an increase was observed in the new model. The abundance of the Na+ Cl- cotransporter is suggested to be decreased in the absence of SGK1 in the new model. Further, the new paper reports that SGK1 is not needed for chronic aldosterone stimulation of ENaC, and that lack of SGK1 reduces the processing of the ENaC protein to a 65 kDa form.