Corrigendum

In the original posting of this article on the APS Articles in PresS Web site (on February 6, 2008), Fig. 3A (inadvertently) contained elements (the top and bottom traces) from a previously published article (Ma et al., Ref. 19, supplemental material). The authors apologize for the error. The problem will be corrected in the final-published version of the manuscript, with a new version of Fig. 3. The complete new figure appears here, with is new legend.

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• Figure 3 (corrected) - Cell-attached patch-clamp recordings, showing the effect of PC2 expression levels on ANG II-induced membrane currents. A: representative traces, displaying single-channel activity before (pre-ANG II) and after (post-ANG II) ANG II stimulation in MCs transfected with pUB empty vector (mock), pkd2 expression plasmids (pkd2), and shRNA-pkd2 RNAi constructs (shRNA-pkd2). Arrows indicate closed state of channels. Downward deflections indicate inward currents. Holding potential was 80 mV (pipette). B: open probability (NPO) of single channels before and after application of ANG II (1 ìM) in mock, pkd2, and shRNA-pkd2 cells; n = no. of cells analyzed. Holding potential was 80 mV (pipette). *P < 0.05, pre-ANG II vs. post-ANG II in the same group of cells. #P < 0.05, compared with pre-ANG II in mock group. C: current-voltage (I-V) relationship curves, showing development of ANG II-induced single-channel currents with changes in membrane potentials in mock-transfected MCs. Membrane potentials were expressed as negative pipette potentials (-Vp). The calculated single-channel conductance was 28.3 pS. The estimated reversal potential was 32 mV (-Vp).