|
|
||||||||
Fig. 8.
ETA and
ETB receptors promote mitogenesis
in human mesangial cells. Quiescent cells were stimulated for 48 h with
readdition of agonists (ET-1 and S6c at 100 nM) and antagonists (BQ-610
and PD-145065 at 100 nM) at 24 h. Cells were preincubated with ET
receptor antagonists for 2 min before addition of ET-1 or S6c.
Bromodeoxyuridine (BrdU) was present throughout the incubation, and
BrdU incorporation into DNA was used to assess mitogenesis as described
in MATERIALS AND METHODS and Ref. 40.
Each bar represents >400 cells analyzed from 2 independent
experiments. ** P < 0.01 vs.
ET-1 alone by
2 analysis.
This article has been cited by other articles:
![]() |
R. Mishra, P. Leahy, and M. S. Simonson Gene expression profile of endothelin-1-induced growth in glomerular mesangial cells Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1109 - C1115. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Sorokin and D. E. Kohan Physiology and pathology of endothelin-1 in renal mesangium Am J Physiol Renal Physiol, October 1, 2003; 285(4): F579 - F589. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Mishra, P. Leahy, and M. S. Simonson Gene expression profiling reveals role for EGF-family ligands in mesangial cell proliferation Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1151 - F1159. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. LEHRKE, R. WALDHERR, E. RITZ, and J. WAGNER Renal Endothelin-1 and Endothelin Receptor Type B Expression in Glomerular Diseases with Proteinuria J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2321 - 2329. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. FOSCHI, A. SOROKIN, P. PRATT, A. MCGINTY, G. L. VILLA, F. FRANCHI, and M. J. DUNN PreproEndothelin-1 Expression in Human Mesangial Cells: Evidence for a p38 Mitogen-Activated Protein Kinase/Protein Kinases-C--Dependent Mechanism J. Am. Soc. Nephrol., June 1, 2001; 12(6): 1137 - 1150. [Abstract] [Full Text] |
||||
![]() |
P. INIGO, J. M. CAMPISTOL, S. LARIO, C. PIERA, B. CAMPOS, M. BESCOS, F. OPPENHEIMER, and F. RIVERA Effects of Losartan and Amlodipine on Intrarenal Hemodynamics and TGF-{beta}1 Plasma Levels in a Crossover Trial in Renal Transplant Recipients J. Am. Soc. Nephrol., April 1, 2001; 12(4): 822 - 827. [Abstract] [Full Text] [PDF] |
||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |