Volume 279, December 2000 Volume 48, December 2000

Pages F1077-F1082: Krieger NS, Parker WR, Alexander KM, and Bushisky DA. "Protaglandins regulate acid-induced cell-mediated bone resorption."

Since publication of our recent article (2), we have been informed that Goldhaber and Rabadjija (1) first demonstrated that indomethacin inhibits acid-induced, cell-mediated calcium efflux from bone. Subsequently, Rabadjija et al. (3) demonstrated that protons stimulate release of prostaglandin E₂ from neonatal mouse calvariae. We sincerely regret that we did not reference these manuscripts and do not wish to take credit for the initial observation that prostaglandin E₂ mediates acid-induced net calcium efflux from bone. We are pleased that our work confirms and extends these important observations.

1. Goldhaber P and Rabadjija L. H⁺ stimulation of cell-mediated bone resorption in tissue culture. Am J Physiol Endocrinol Metab 253: E90-E98, 1987.

2. Krieger NS, Parker WR, Alexander KM, and Bushinsky DA. Prostaglandins regulate acid-induced cell-mediated bone resorption. Am J Physiol Renal Physiol 279: F1077-1082, 2000.

3. Rabadjija L., Brown EM, Swartz SL, Chen CJ, and Goldhaber P. H⁺-stimulated release of prostaglandin E₂ and cyclic adenosine 3',5'-monophosphoric acid and their relationship to bone resorption in neonatal mouse calvaria cultures. Bone Miner 11: 295-304, 1990.