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Corrigendum

Volume 62, December 2007

Pages F1935–F1943.

Mo L, Liaw L, Evan AP, Sommer AJ, Lieske JC, and Wu. X-R. Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both. Am J Physiol Renal Physiol 293: F1935–F1943 (doi:10.1152/ajprenal.00383.2007).

On pp. F1938 and F1941, respectively, Figs. 2C and 4E were printed incorrectly. Corrected Figs. 2 and 4 appear below with their respective legends.

View larger version (37K): [in this window] [in a new window]   Fig. 2. Renal calcinosis in mice lacking urinary macromolecules. Representative cross-sections of renal papillary regions of WT (A and E), OPN-null (B and F), THP-null (C and G), and OPN/THP-double null mice (D and H) were stained with von Kossa method that specifically detects calcium deposits in the tissue. Whereas WT mice were crystal-free, the null mice exhibited multiple calcium crystals (dark color; B–D) that at high magnification were primarily interstitial (F–H). L denotes the lumen of the collecting tubules. Magnification: A–D, x50; F–H, x200. I: chemical composition of naturally occurring, renal papillary crystal deposits by µ-FTIR spectroscopy. Top: 2 spectra were standard spectra from calcium oxalate (CaOx) and calcium phosphate (hydroxyapatite), respectively. Bottom: spectrum was obtained from the papillary tissue from a crystal-free WT mouse. Middle: 2 spectra were obtained from papillary crystals of an OPN-null mouse and a THP-null mouse, respectively, both containing exclusively hydroxyapatite.

View larger version (101K): [in this window] [in a new window]   Fig. 4. Susceptibility of macromolecule-deficient mice to renal crystallization and stone formation under hyperoxaluric conditions. A–D: urine samples examined with dark-field microscope equipped with polarized light showing no crystal in WT mice (A), small amounts of crystals in OPN-null mice (B), moderate amounts of crystals in THP-null mice (C), and large amounts of crystals in OPN/THP-null mice (D). E–H: von Kossa staining of outer medullary regions of the kidneys showing the absence of any calcium crystals in a WT mouse (E), and increasing amounts of crystals in OPN-null mouse (F), THP-null mouse (G), and OPN/THP-double null mouse (H). I–L: von Kossa staining showing renal stones at the tips of severely dilated ducts of Bellini of 2 THP-null mice (I and J) and in the renal pelvis of an OPN-null mouse (K) and an OPN/THP-null mouse (L). Magnification x100. M: µ-FTIR spectroscopy of deep medullary crystals stained positive with von Kossa method. Top: 2 spectra were standard spectra from calcium oxalate and calcium phosphate (hydroxyapatite). Bottom: spectrum was from the deep medullary tissue of a WT mouse. Middle: 2 spectra were obtained from an OPN-null mouse and a THP-null mouse that had been treated with vitamin D3 and ethylene glycol, showing identical profiles to that of calcium oxalate.

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