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Articles in PresS, published online ahead of print April 16, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00005.2002
Submitted on January 3, 2002
Accepted on April 9, 2002
1 Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
* To whom correspondence should be addressed. E-mail: Michel.Baum{at}UTSouthwestern.edu.
The early proximal tubule preferentially reabsorbs organic solutes and bicarbonate over chloride ions resulting in a luminal fluid with a higher chloride concentration than that in blood. From this late proximal tubular fluid, half of NaCl reabsorption by the adult proximal tubule is active and transcellular and half is passive and paracellular. The purpose of the present in vitro microperfusion study was to determine the characteristics of passive chloride transport and permeability properties of the adult and neonatal proximal straight tubule (PST). In tubules perfused with a late proximal tubular fluid, net passive chloride flux was 131.7±37.7 pmol/mm.min in adult tubules and -17.1±23.3 pmol/mm.min in neonatal proximal tubules (p<0.01). Chloride permeability was 10.94±5.21 x10-5 cm/sec in adult proximal tubules and -1.26±1.84 x10-5 cm/sec in neonatal proximal tubules (p<0.05). Thus, neonatal PST have a chloride permeability not different from zero and have no net passive chloride transport. Bicarbonate permeability is also less in neonates than adults in this segment (-0.07±0.03 x10-5 vs 0.93±0.27 x10-5 cm/sec, p<0.01). Neonatal PST have higher PNa/PCl and PHCO3/PCl ratios than adult PST. However, mannitol and sucrose permeabilities were not different in adult proximal tubules and neonatal PST. The transepithelial resistance was measured using current injection and cable analysis. The resistance was 6.7±0.7 
.cm2 in adult tubules and 11.3±1.4 .cm2 in neonatal proximal straight tubules (p<0.01). In conclusion, there are significant maturational changes in the characteristics of the PST paracellular pathway affecting transport in this nephron segment.
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