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1 Medicine, Loyola University Medical Center, Maywood, Illinois, United States; Medicine, Hines VA Hospital, Maywood, Illinois, United States
2 Pathology, Loyola University Medical Center, Maywood, Illinois, United States
3 Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois, United States
* To whom correspondence should be addressed. E-mail: abidani{at}lumc.edu.
The rat streptozotocin (STZ) induced diabetes model is widely used to investigate the pathogenesis of diabetic nephropathy. However, overt nephropathy is inexplicably slow to develop in this as compared to renal mass reduction (RMR) models. To examine if BP differences correlated with the time course of GS, BP was measured continuously throughout the course by radiotelemetry in control (n=17), partially insulin treated STZ-diabetes (average blood glucose 364±15 mg/dl) (n=15) and two normotensive RMR models (systolic BP < 140 mmHg) - uninephrectomy, UNX (n=16); and 
RMR by surgical excision; RK-NX (n=12) in Sprague-Dawley rats. Proteinuria and glomerulosclerosis (GS) were assessed at ~16-20 weeks (all groups) and at 36-40 weeks (all groups except RK-NX). At 16 weeks, significantly greater proteinuria and GS had developed in the RK-NX, as compared to the other 3 groups (not different from each other). By 36-40 weeks, substantial proteinuria and GS had also developed in the UNX group, but both the control and the STZ-diabetic rats exhibited comparable modest proteinuria and minimal GS. Systolic BP (mmHg) was significantly reduced in the STZ-diabetic rats (116±1.1) as compared to both control (124±1.0) and RMR groups (128±1.2; 130±3.0) (p < 0.01). Similarly, 'BP load' as estimated by BP power spectral analysis was also lower in the STZ-diabetic rats. Given the known protective effects of BP reductions on the progression of diabetic nephropathy, it is likely that this spontaneous reduction in ambient BP contributes to the slow development of GS in the STZ-diabetes as compared to the normotensive RMR models.
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