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1 Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, Japan; Department of Optical Science and Technology, Tokushima University Faculty of Engineering, Tokushima-shi, Tokushima, Japan
2 Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, Japan
3 Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, Japan; Department of Periodontology, Gadjah Mada University Faculty of Dentistry, Jogjakarta, D.I. Jogjakarta, Indonesia
4 Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, Japan; Membrane Biology Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
5 Department of Biosciences, Kyushu Dental College, Kitakyushu-shi, Kitakyushu, Japan
6 Faculty of Food and Nutrition,, Kyushu Nutrition Welfare University, Kitakyushu-shi, Kitakyushu, Japan
* To whom correspondence should be addressed. E-mail: hosoi{at}dent.tokushima-u.ac.jp.
Aquaporin 2 (AQP2) is responsible for the concentration of urine in the kidney collecting tubule under the regulation of vasopressin. The mRNA level of this water channel was found to be extremely reduced in polydipsic STR/N mice compared with that of normal ICR mice. In male mice, the reduction in the AQP2 mRNA level was not evident at 3 weeks of age, at which time the water intake was not increased at all. At 10 weeks of age, however, the AQP2 mRNA level was reduced to 10% of that of the control mice, whereas the water intake was increased by 36%. When STR/N mice were 44 weeks old, the water intake became 5 times of that of the control ICR mice, and the AQP2 mRNA level in these polydipsic mice was only approx. 5% of the control one. Similar changes were observed in the AQP2 protein level, suggesting that the AQP2 mRNA level reflects its protein level. These inverted changes in the AQP2 mRNA level and water intake were also evident in females. These data imply that polydipsia in STR/N mice may have affected the AQP2 mRNA transcription in the kidney, resulting in reduced AQP2 expression, which would contribute to a reduction in over-retention of water.
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