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Am J Physiol Renal Physiol (March 26, 2008). doi:10.1152/ajprenal.00050.2008
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Submitted on January 29, 2008
Accepted on March 19, 2008

Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces

Masanori Kitamura1*

1 Department of Molecular Signaling, University of Yamanashi, Chuo, Yamanashi, Japan

* To whom correspondence should be addressed. E-mail: masanori{at}yamanashi.ac.jp.

A number of pathophysiological insults lead to accumulation of unfolded proteins in the endoplasmic reticulum (ER) and cause ER stress. In response to accumulation of unfolded/misfolded proteins, cells adapt themselves to the stress condition via the unfolded protein response (UPR). For the cells, UPR is a double-edged sword. It triggers both prosurvival and proapoptotic signals. ER stress and UPR may, therefore, be involved in a diverse range of pathological situations. However, currently, information is limited regarding roles of ER stress and UPR in the renal pathophysiology. This review describes current knowledge on the relationship between ER stress and diseases and summarizes evidence for the link between ER stress/UPR and renal diseases.




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