| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana, United States
2 Department of Physiology, SL39, Tulane University School of Medicine, New Orleans,, Louisiana, United States
* To whom correspondence should be addressed. E-mail: hkobori{at}tulane.edu.
Chronic angiotensin (Ang) II infusions into rats lead to augmented intrarenal levels of AngII and inflammatory factors, impaired renal function, and progressive hypertension. Residual effects persist after cessation of AngII infusions as manifested by a hypertensive response to high salt intake. This study was performed to determine the residual cytokines and chemokines following the cessation of AngII infusion. Male Sprague-Dawley rats, maintained on a normal diet, received either a sham operation or continuous AngII infusion (120 ng/min) subcutaneously via minipumps. The AngII-infused rats were further subdivided into 3 subgroups. Minipumps were removed on day 12 with subsequent harvesting of kidneys at 0, 3 and 6 days after cessation of AngII infusion. After 12 days of AngII infusion, systolic blood pressure (BP), interstitial fibrosis, preglomerular hypertrophy, and interstitial macrophage infiltration were significantly enhanced compared to the shams. By 3 days following the cessation of AngII infusion, systolic BP was normalized; however, interstitial fibrosis and preglomerular hypertrophy were still present. Furthermore, increased interstitial macrophage infiltration was still present 6 days after cessation of AngII infusion. Importantly, augmented mRNA levels of monocyte chemotactic protein (MCP)-1 (1.55±0.15 vs 1.00±0.13, relative ratio) and transforming growth factor-beta (TGF-b) 1 (1.52±0.16 vs 1.00±0.08) persisted 6 days after the withdrawal of AngII infusion (1.60±0.20 for MCP-1 and 1.43±0.17 for TGF-b1). Thus, the AngII-induced activation of MCP-1 and TGF-b1 is sustained and may account for the persistent effect of chronic AngII infusions on interstitial macrophage infiltration, suggesting a possible mechanism for the development of salt sensitivity in AngII-dependent hypertension.
This article has been cited by other articles:
|
|
 |
|
  Y. Zhang, J. C. Naggar, C. M. Welzig, D. Beasley, K. S. Moulton, H.-J. Park, and J. B. Galper Simvastatin Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-Knockout Mice: Possible Role of ERK Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1764 - 1771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. I. Ager, J. Neo, and C. Christophi The renin-angiotensin system and malignancy Carcinogenesis, September 1, 2008; 29(9): 1675 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kobori, A. Katsurada, K. Miyata, N. Ohashi, R. Satou, T. Saito, Y. Hagiwara, K. Miyashita, and L. G. Navar Determination of plasma and urinary angiotensinogen levels in rodents by newly developed ELISA Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1257 - F1263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Graciano, A. Nishiyama, K. Jackson, D. M. Seth, R. M. Ortiz, M. C. Prieto-Carrasquero, H. Kobori, and L. G. Navar Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension Am J Physiol Renal Physiol, January 1, 2008; 294(1): F161 - F169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Muller, N. Schweitzer, O. Johren, P. Dominiak, and W. Raasch Angiotensin II stimulates the reactivity of the pituitary-adrenal axis in leptin-resistant Zucker rats, thereby influencing the glucose utilization Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E802 - E810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Katsurada, Y. Hagiwara, K. Miyashita, R. Satou, K. Miyata, N. Ohashi, L. G. Navar, and H. Kobori Novel sandwich ELISA for human angiotensinogen Am J Physiol Renal Physiol, September 1, 2007; 293(3): F956 - F960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kobori, Y. Ozawa, R. Satou, A. Katsurada, K. Miyata, N. Ohashi, N. Hase, Y. Suzaki, C. D. Sigmund, and L. G. Navar Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice Am J Physiol Renal Physiol, September 1, 2007; 293(3): F938 - F945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ozawa and H. Kobori Crucial role of Rho-nuclear factor-{kappa}B axis in angiotensin II-induced renal injury Am J Physiol Renal Physiol, July 1, 2007; 293(1): F100 - F109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Coleman, J. J. Minor, L. E. Burt, B. A. Thornhill, M. S. Forbes, and R. L. Chevalier Angiotensin AT1-receptor inhibition exacerbates renal injury resulting from partial unilateral ureteral obstruction in the neonatal rat Am J Physiol Renal Physiol, July 1, 2007; 293(1): F262 - F268. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
