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1 Hospital for Children and Adolescents, University of Erlangen-Nuremberg, Erlangen, Germany
2 Nephrology and Hypertension, University of Erlangen-Nuremberg, Erlangen, Germany
3 Medicine II, City Hospital, Augsburg, Germany
* To whom correspondence should be addressed. E-mail: karl.hilgers{at}rzmail.uni-erlangen.de.
Induction of streptozotocin (STZ) diabetes in hypertensive rats transgenic for the mouse ren-2 gene (TGR) has been described as a model of progressive diabetic nephropathy. We investigated the long-term course of STZ diabetes in TGR and appropriate Sprague-Dawley control rats (SD), and tested the role of angiotensin-dependent hypertension by treating rats with the angiotensin II type 1 receptor blocker losartan (1 mg/kg/day) via osmotic minipumps. Five weeks after STZ injection, diabetes developed in TGR and SD rats. Urinary albumin excretion was increased by diabetes and, to a much higher degree, by hypertension. The effects of hypertension and diabetes were not additive, and only the effects of hypertension were ameliorated by losartan. A similar pattern was observed for cell proliferation and macrophage infiltration in the kidney. In contrast, the effects of hypertension and diabetes on glomerular collagen IV accumulation were additive 5 weeks after STZ injection. In a long-term study for 20 weeks after STZ, survival was better in STZ treated TGR than in normoglycemic TGR while all SD rats survived. Impaired creatinine clearance, increased macrophage infiltration as well as glomerular and interstitial matrix deposition were prominent in TGR, compared to SD, regardless of the presence or absence of diabetes. In conclusion, STZ diabetes in TGR may be useful to study glomerular and interstitial matrix deposition early in the course of diabetes. However, the long-term course of this animal model resembles severe hypertensive nephrosclerosis rather than progressive diabetic nephropathy.
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