| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Division of Nephrology, The Penn State College of Medicine, Hershey, PA, USA
2 Division of Nephrology, The Penn State College of Medicine, Hershey, PA, USA; Milton S. Hershey Medical Center, Hershey, PA, USA; Lebanon VA Medical Center, Lebanon, PA, USA
* To whom correspondence should be addressed. E-mail: wreeves{at}psu.edu.
Cisplatin produces acute renal failure in humans and mice. Previous studies have shown that cisplatin upregulates the expression of TNF-
in mouse kidney and that inhibition of either the release or action of TNF- protects the kidney from cisplatin induced nephrotoxicity. In this study, we examined the effect of cisplatin on the expression of TNFR1 and TNFR2 in the kidney and the role of each receptor in mediating cisplatin nephrotoxicity. Injection of cisplatin into C57BL6 mice led to an upregulation of TNFR1 and TNFR2 mRNA levels in the kidney. The upregulation of TNFR2 but not TNFR1 was blunted in TNF- deficient mice indicating ligand dependent upregulation of TNFR2. To study the roles of each receptor, we administered cisplatin to TNFR1 or TNFR2 deficient mice. TNFR2 deficient mice developed less severe renal dysfunction and showed reduced necrosis and apoptosis and leukocyte infiltration into the kidney when compared with either TNFR1 deficient or wild type mice. Moreover, renal TNF- expression, ICAM-1 expression and serum TNF- levels were lower in TNFR2 deficient mice compared with wild type or TNFR1 deficient mice treated with cisplatin. These results indicate that TNFR2 participates in cisplatin-induced renal injury in mice and may play an important role in TNF- mediated inflammation in the kidney in response to cisplatin.
This article has been cited by other articles:
|
|
 |
|
  X. Wu, R. Guo, P. Chen, Q. Wang, and P. N. Cunningham TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism Am J Physiol Renal Physiol, August 1, 2009; 297(2): F316 - F326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Misaki, T. Yamamoto, S. Suzuki, H. Fukasawa, A. Togawa, N. Ohashi, H. Suzuki, Y. Fujigaki, T. Oda, C. Uchida, et al. Decrease in Tumor Necrosis Factor-{alpha} Receptor-Associated Death Domain Results from Ubiquitin-Dependent Degradation in Obstructive Renal Injury in Rats Am. J. Pathol., July 1, 2009; 175(1): 74 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Han, J. Yue, and R. W. Chesney Functional TauT Protects Against Acute Kidney Injury J. Am. Soc. Nephrol., June 1, 2009; 20(6): 1323 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Elizur, T. L. Adair-Kirk, D. G. Kelley, G. L. Griffin, D. E. deMello, and R. M. Senior Tumor Necrosis Factor-{alpha} from Macrophages Enhances LPS-Induced Clara Cell Expression of Keratinocyte-Derived Chemokine Am. J. Respir. Cell Mol. Biol., January 1, 2008; 38(1): 8 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Lu, D.-J. Oh, B. Dursun, Z. He, T. S. Hoke, S. Faubel, and C. L. Edelstein Increased Macrophage Infiltration and Fractalkine Expression in Cisplatin-Induced Acute Renal Failure in Mice J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 111 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Yu, J. Megyesi, R. L. Safirstein, and P. M. Price Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo Am J Physiol Renal Physiol, July 1, 2007; 293(1): F52 - F59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ramesh, B. Zhang, S. Uematsu, S. Akira, and W. B. Reeves Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice Am J Physiol Renal Physiol, July 1, 2007; 293(1): F325 - F332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ramesh, S. R. Kimball, L. S. Jefferson, and W. B. Reeves Endotoxin and cisplatin synergistically stimulate TNF-{alpha} production by renal epithelial cells Am J Physiol Renal Physiol, February 1, 2007; 292(2): F812 - F819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, N. Pabla, C.-Y. Wang, W. Wang, P. V. Schoenlein, and Z. Dong Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53 Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1300 - F1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kadhim, M. Khalifa, P. Deltenre, G. Casimir, and G. Sebire Molecular mechanisms of cell death in periventricular leukomalacia. Neurology, July 25, 2006; 67(2): 293 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Zager, A. C. M. Johnson, S. Y. Hanson, and S. Lund Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-{alpha} generation and systemic release Am J Physiol Renal Physiol, August 1, 2005; 289(2): F289 - F297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Li, N. Gokden, M. D. Okusa, R. Bhatt, and D. Portilla Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF Am J Physiol Renal Physiol, August 1, 2005; 289(2): F469 - F480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jiang, X. Yi, S. Hsu, C.-Y. Wang, and Z. Dong Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1140 - F1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Li, R. Bhatt, J. Megyesi, N. Gokden, S. V. Shah, and D. Portilla PPAR-{alpha} ligand ameliorates acute renal failure by reducing cisplatin-induced increased expression of renal endonuclease G Am J Physiol Renal Physiol, November 1, 2004; 287(5): F990 - F998. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
