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Am J Physiol Renal Physiol (November 13, 2001). doi:10.1152/ajprenal.00126.2001
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Articles in PresS, published online ahead of print November 13, 2001
Am J Physiol Renal Physiol, 10.1152/ajprenal.00126.2001
Submitted on April 18, 2001
Accepted on November 2, 2001

Role of Tyrosine Kinase and p44/42 MAPK In D2-like Receptor-Mediated Stimulation Of Na+, K+, ATPase In Kidney

Vihang A Narkar1, Tahir Hussain1, and Mustafa F Lokhandwala1*

1 Institute for Cardiovascular Studies, University of Houston, Houston, TX, USA

* To whom correspondence should be addressed. E-mail: MLokhandwala{at}uh.edu.

We have previously shown that dopamine D2-like receptor activation causes stimulation of Na+, K+, ATPase (NKA) activity in the proximal tubules of the rat kidney. The present study was designed to investigate the cellular signaling mechanisms mediating this response to D2-like receptor activation. We measured the stimulation of NKA activity by bromocriptine (D2-like receptor agonist) in absence and presence of PD 98059 (p44/42 MAPK kinase inhibitor) and genistein (tyrosine kinase inhibitor) in renal proximal tubules. Both the agents inhibited bromocriptine-mediated stimulation of NKA, suggesting the involvement of p44/42 MAPK and tyrosine kinase in this response. Additionally, we found that bromocriptine increased the phosphorylation of p44/42 MAPK in the proximal tubules, which was blocked by PD 98059 and genistein. These results show that D2-like receptor activation causes stimulation of NKA activity via a tyrosine kinase-p44/42 MAPK pathway in the proximal tubules of kidney.




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