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Articles in PresS, published online ahead of print August 27, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00147.2002
Submitted on April 17, 2002
Accepted on August 20, 2002
1 Department of Medicine, University of Texas, Medical School at Houston, Houston, Texas, USA; Integrative Biology and Pharmacology, University of Texas, Medical School at Houston, Houston, Texas, USA
2 Department of Medicine, University of Texas, Medical School at Houston, Houston, Texas, USA
3 Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
4 Integrative Biology and Pharmacology, University of Texas, Medical School at Houston, Houston, Texas, USA
5 Department of Medicine, University of Florida, College of Medicine, Gainesville, Florida, USA
* To whom correspondence should be addressed. E-mail: Susan.M.Wall{at}uth.tmc.edu.
Pendrin is an anion exchanger expressed in type B intercalated cells of the cortical collecting duct (CCD). Whether pendrin localizes to other nephron segments with intercalated cells is unknown. Moreover, whether pendrin is expressed in proximal tubule is debated. Thus, the distribution of pendrin mRNA and protein expression in mouse kidney was investigated using light and electron microscopic immunohistochemistry and quantitative real time PCR. We observed that pendrin mRNA is expressed mainly in cortex. Within cortex, pendrin mRNA is at least 5-fold higher in cortical collecting duct (CCD) and the connecting tubule (CNT) than in the other segments. Pendrin protein was observed in a subset of cells within the distal convoluted tubule (DCT) as well as in type B and in non-A, non-B intercalated cells of the CNT and CCD. In B intercalated cells, pendrin immunoreactivity was highest in apical cytoplasmic vesicles with little immunolabel along the apical plasma membrane. In non-A, non-B intercalated cells intense pendrin immunoreactivity was detected along the apical plasma membrane. These differences in the subcellular distribution of pendrin immunolabel were confirmed by morphometric analysis. In conclusion, pendrin is expressed in the mouse DCT, CCD, and CNT along the apical plasma membrane of non-A, non-B intercalated cells and in subapical cytoplasmic vesicles of type B intercalated cells.
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