| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Laboratory of Epithelial Cell Biology, Renal-Electrolyte Division, Universty of Pittsburgh School of Medicine, United States
2 Laboratory of Epithelial Cell Biology, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, United States
3 Laboratory of Epithelial Cell Biology, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
4 Medicine/Renal-Electrolyte, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
The maintenance of apical and basolateral membrane domains with distinct protein and lipid compositions is necessary for the proper function of polarized epithelial cells. Delivery of cargo to the basolateral surface is thought to be mediated by the interaction of cytoplasmically-disposed sorting signals with sorting receptors, whereas apically-destined cargoes are sorted via mechanisms dependent on cytoplasmic, glycan-mediated, or lipid-interacting sorting signals. Apical and basolateral cargo are delivered to the surface in discrete tubular and vesicular carriers that bud from the trans-Golgi network (TGN). While it has long been thought that the TGN is the primary compartment in which apical and basolateral cargoes are segregated, recent studies suggest that sorting may begin earlier along the biosynthetic pathway. Moreover, rather than being delivered directly from the TGN to the cell surface, at least a subset of biosynthetic cargo appears to transit recycling endosomes en route to the plasma membrane. The implications and limitations of these challenges to the conventional model for how proteins are sorted and trafficked along the biosynthetic pathway are discussed.
This article has been cited by other articles:
|
|
 |
|
  O. A. Weisz and E. Rodriguez-Boulan Apical trafficking in epithelial cells: signals, clusters and motors J. Cell Sci., December 1, 2009; 122(23): 4253 - 4266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Diaz, D. Gravotta, A. Deora, R. Schreiner, J. Schoggins, E. Falck-Pedersen, and E. Rodriguez-Boulan Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells PNAS, July 7, 2009; 106(27): 11143 - 11148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Vagin, J. A. Kraut, and G. Sachs Role of N-glycosylation in trafficking of apical membrane proteins in epithelia Am J Physiol Renal Physiol, March 1, 2009; 296(3): F459 - F469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Hansen, L.-L. Niels-Christiansen, and E. M. Danielsen Leptin and the Obesity Receptor (OB-R) in the Small Intestine and Colon: A Colocalization Study J. Histochem. Cytochem., July 1, 2008; 56(7): 677 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cancino, C. Torrealba, A. Soza, M. I. Yuseff, D. Gravotta, P. Henklein, E. Rodriguez-Boulan, and A. Gonzalez Antibody to AP1B Adaptor Blocks Biosynthetic and Recycling Routes of Basolateral Proteins at Recycling Endosomes Mol. Biol. Cell, December 1, 2007; 18(12): 4872 - 4884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Manderson, J. G. Kay, L. A. Hammond, D. L. Brown, and J. L. Stow Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNF{alpha} J. Cell Biol., October 3, 2007; 178(1): 57 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Carlsson, M. C Carlsson, and H. Leffler Intracellular sorting of galectin-8 based on carbohydrate fine specificity Glycobiology, September 1, 2007; 17(9): 906 - 912. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
