| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Articles in PresS, published online ahead of print July 16, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00178.2002
Submitted on May 7, 2002
Accepted on July 10, 2002
1 Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
2 Department of Medical Physiology, Division of Renal and Cardiovascular Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: mcdonoug{at}hsc.usc.edu.
Acute hypertension inhibits proximal tubule (PT) sodium reabsorption. The resultant increase in NaCl delivery to the macula densa suppresses renin release. We tested whether the sustained pressure-induced inhibition of PT sodium reabsorption requires renin-mediated decrease in angiotensin II (Ang II) levels. Plasma [Ang II] of anesthesized Sprague-Dawley rats was clamped by simultaneous infusion of the angiotensin-converting enzyme inhibitor captopril (12 µg/min) and Ang II (20 ng/kg.min). Blood pressure (BP) was increased 50 mmHg for 20 min by arterial constriction ± Ang II clamp, or sham operation. This acute hypertension increased urine output and endogenous Li+ clearance and these responses were blunted 40-50% in Ang II clamped rats. Acute hypertension provoked a rapid redistribution of NHE3 out of apical brush border membranes (21 ± 4% decrease of total NHE3 abundance) to endosomal/lysosomal membranes (16 ± 6% increase of total). In Ang II clamped rats, acute hypertension also provoked disappearance of NHE3 from the apical membranes (27 ± 2% decrease of total), but NHE3 was shifted to membranes enriched in intermicrovillar cleft and dense apical tubules (step 1) rather than endosomal/lysosomal membranes (step 2). This difference was independently confirmed by confocal analysis. In contrast, the pressure-induced redistribution of NaPi2 was not altered by Ang II clamp. We conclude that the responses to acute hypertension, including diuresis and redistribution of proximal tubule NHE3 into intracellular membranes, require a responsive renin-angiotensin system and that the responses may be induced by the sustained increase in NaCl delivery to the macula densa during acute hypertension.
This article has been cited by other articles:
|
|
 |
|
  D. R. Yingst, A. Araghi, T. M. Doci, R. Mattingly, and W. H. Beierwaltes Decreased renal perfusion rapidly increases plasma membrane Na-K-ATPase in rat cortex by an angiotensin II-dependent mechanism Am J Physiol Renal Physiol, November 1, 2009; 297(5): F1324 - F1329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Seeliger, T. Wronski, M. Ladwig, L. Dobrowolski, T. Vogel, M. Godes, P. B. Persson, and B. Flemming The renin-angiotensin system and the third mechanism of renal blood flow autoregulation Am J Physiol Renal Physiol, June 1, 2009; 296(6): F1334 - F1345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Lee, A. D. M. Riquier, L. E. Yang, P. K. K. Leong, A. B. Maunsbach, and A. A. McDonough Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles Am J Physiol Renal Physiol, April 1, 2009; 296(4): F810 - F818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. C. Li and J. L. Zhuo Intracellular ANG II directly induces in vitro transcription of TGF-{beta}1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors Am J Physiol Cell Physiol, April 1, 2008; 294(4): C1034 - C1045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Padia, B. A. Kemp, N. L. Howell, M.-C. Fournie-Zaluski, B. P. Roques, and R. M. Carey Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor-Mediated Natriuresis In Rats Hypertension, February 1, 2008; 51(2): 460 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Yang, P. K. K. Leong, and A. A. McDonough Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1197 - F1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Donowitz and X. Li Regulatory Binding Partners and Complexes of NHE3 Physiol Rev, July 1, 2007; 87(3): 825 - 872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. C. Li and J. L. Zhuo Selective knockdown of AT1 receptors by RNA interference inhibits Val5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells Am J Physiol Cell Physiol, July 1, 2007; 293(1): C367 - C378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Kocinsky, D. W. Dynia, T. Wang, and P. S. Aronson NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity Am J Physiol Renal Physiol, July 1, 2007; 293(1): F212 - F218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples and B. Braam Assessment of renal autoregulation Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1105 - F1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. K. Leong, L. E. Yang, C. S. Landon, A. A. McDonough, and K.-P. Yip Phenol injury-induced hypertension stimulates proximal tubule Na+/H+ exchanger activity Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1543 - F1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. K. Leong, A. Devillez, M. B. Sandberg, L. E. Yang, D. K. P. Yip, J. B. Klein, and A. A. McDonough Effects of ACE inhibition on proximal tubule sodium transport Am J Physiol Renal Physiol, April 1, 2006; 290(4): F854 - F863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Yang, A. B. Maunsbach, P. K.K. Leong, and A. A. McDonough Redistribution of Myosin VI from Top to Base of Proximal Tubule Microvilli during Acute Hypertension J. Am. Soc. Nephrol., October 1, 2005; 16(10): 2890 - 2896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. T. Noonan, A. L. Woo, M. L. Nieman, V. Prasad, P. J. Schultheis, G. E. Shull, and J. N. Lorenz Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R685 - R691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Yang, A. B. Maunsbach, P. K. K. Leong, and A. A. McDonough Differential traffic of proximal tubule Na+ transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes Am J Physiol Renal Physiol, November 1, 2004; 287(5): F896 - F906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. K. Leong, L. E. Yang, H. W. Lin, N. H. Holstein-Rathlou, and A. A. McDonough Acute hypotension induced by aortic clamp vs. PTH provokes distinct proximal tubule Na+ transporter redistribution patterns Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R878 - R885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Dos Santos, A. J. Dahly-Vernon, K. M. Hoagland, and R. J. Roman Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R58 - R68. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
