| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Articles in PresS, published online ahead of print July 24, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00199.2002
Submitted on May 22, 2002
Accepted on July 17, 2002
1 Renal Service and Laboratory, Instituto de Investigaciones Biomedicas (INBIOMED), Hospital Universitario, Universidad del Zulia, Maracaibo, Zulia, Venezuela
* To whom correspondence should be addressed. E-mail: bri{at}iamnet.com.
Recent evidence suggests that salt-sensitive hypertension develops as a consequence of renal infiltration with immunocompetent cells. We investigated if proteinuria, which is known to induce interstitial nephritis, causes salt-sensitive hypertension. Female Lewis rats received 2g of bovine serum albumin intraperitoneally daily for 2 weeks. Following protein overload (PO), six weeks of a high salt diet induced hypertension (systolic blood pressure, SBP= 156 ± 11.8 mmHg) while rats that remained on a normal salt diet and control rats (without PO) on a high salt diet were normotensive. Administration of mycophenolate mofetil (20mg/kg/day) during PO resulted in prevention of proteinuria-related interstitial nephritis, reduction of renal angiotensin II positive cells and oxidative stress (superoxide positive cells and renal malondialdehyde content) and in resistance to the hypertensive effect of the high salt diet (SBP= 129 ± 12.2 mmHg). The present studies support the participation of renal inflammatory infiltrate in the pathogenesis of salt-sensitive hypertension and provide a direct link between two risk factors of progressive renal damage: proteinuria and hypertension.
This article has been cited by other articles:
|
|
 |
|
  E. Tapia, D. J. Sanchez-Gonzalez, O. N. Medina-Campos, V. Soto, C. Avila-Casado, C. M. Martinez-Martinez, R. J. Johnson, B. Rodriguez-Iturbe, J. Pedraza-Chaverri, M. Franco, et al. Treatment with pyrrolidine dithiocarbamate improves proteinuria, oxidative stress, and glomerular hypertension in overload proteinuria Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1431 - F1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Pechman, D. P. Basile, H. Lund, and D. L. Mattson Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1234 - R1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Quiroz, A. Ferrebuz, F. Romero, N. D. Vaziri, and B. Rodriguez-Iturbe Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction Am J Physiol Renal Physiol, February 1, 2008; 294(2): F336 - F344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bravo, Y. Quiroz, A. Ferrebuz, N. D. Vaziri, and B. Rodriguez-Iturbe Mycophenolate mofetil administration reduces renal inflammation, oxidative stress, and arterial pressure in rats with lead-induced hypertension Am J Physiol Renal Physiol, August 1, 2007; 293(2): F616 - F623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Franco, F. Martinez, Y. Quiroz, O. Galicia, R. Bautista, R. J. Johnson, and B. Rodriguez-Iturbe Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R251 - R256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rodriguez-Iturbe, L. Sepassi, Y. Quiroz, Z. Ni, and N. D. Vaziri Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence J Appl Physiol, January 1, 2007; 102(1): 255 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ozawa, H. Kobori, Y. Suzaki, and L. G. Navar Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions Am J Physiol Renal Physiol, January 1, 2007; 292(1): F330 - F339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-W. Gu, N. Tian, M. Shparago, W. Tan, A. P. Bailey, and R. D. Manning Jr. Renal NF-{kappa}B activation and TNF-{alpha} upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1817 - R1824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Franco, F. Martinez, B. Rodriguez-Iturbe, R. J. Johnson, J. Santamaria, A. Montoya, T. Nepomuceno, R. Bautista, E. Tapia, and J. Herrera-Acosta Angiotensin II, interstitial inflammation, and the pathogenesis of salt-sensitive hypertension Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1281 - F1287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Herrera, A. Ferrebuz, E. G. MacGregor, and B. Rodriguez-Iturbe Mycophenolate Mofetil Treatment Improves Hypertension in Patients with Psoriasis and Rheumatoid Arthritis J. Am. Soc. Nephrol., December 1, 2006; 17(12_suppl_3): S218 - S225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Fujihara, C. R. Sena, D. M. A. C. Malheiros, A. L. Mattar, and R. Zatz Short-term nitric oxide inhibition induces progressive nephropathy after regression of initial renal injury Am J Physiol Renal Physiol, March 1, 2006; 290(3): F632 - F640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rodriguez-Iturbe and R. J. Johnson Role of inflammatory cells in the kidney in the induction and maintenance of hypertension Nephrol. Dial. Transplant., February 1, 2006; 21(2): 260 - 263. [Full Text] [PDF]
|
|
|
|
|
|
M. M. van Timmeren, S. J. L. Bakker, C. A. Stegeman, R. O. B. Gans, and H. van Goor Addition of oleic acid to delipidated bovine serum albumin aggravates renal damage in experimental protein-overload nephrosis Nephrol. Dial. Transplant., November 1, 2005; 20(11): 2349 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Rodriguez-Iturbe, N. D. Vaziri, J. Herrera-Acosta, and R. J. Johnson Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all Am J Physiol Renal Physiol, April 1, 2004; 286(4): F606 - F616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Mattson, M. P. Kunert, M. L. Kaldunski, A. S. Greene, R. J. Roman, H. J. Jacob, and A. W. Cowley Jr Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats Physiol Genomics, January 15, 2004; 16(2): 194 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nava, Y. Quiroz, N. Vaziri, and B. Rodriguez-Iturbe Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats Am J Physiol Renal Physiol, March 1, 2003; 284(3): F447 - F454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rodriguez-Iturbe, C.-D. Zhan, Y. Quiroz, R. K. Sindhu, and N. D. Vaziri Antioxidant-Rich Diet Relieves Hypertension and Reduces Renal Immune Infiltration in Spontaneously Hypertensive Rats Hypertension, February 1, 2003; 41(2): 341 - 346. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
