| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine/Nephrology, Hannover Medical School, Hannover, Germany
2 Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine, Mount Sinai Medical Center, New York, NY, USA
3 Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA
4 Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
* To whom correspondence should be addressed. E-mail: charron{at}aecom.yu.edu.
Kidney disease is a major complication of diabetes and poor glycemic control is associated with the development of diabetic nephropathy. The precise mechanisms that lead to diabetic kidney disease still remain largely unknown and are under current investigation. Because glucose transporters in the kidney play an important role in the local maintenance of intracellular glucose and plasma glucose homeostasis, the tissue distribution and regulation of glucose transporter GLUT8, a new member of the glucose transporter family with important functions in cellular survival, was examined. To understand the normal regulation of GLUT8 expression in response to metabolic signals fasting and feeding conditions were studied. Additionally, GLUT8 expression was studied using two different models of insulin resistance, GLUT4 -/- and db/db mice. GLUT8 was localized to glomerular podocytes and tubular epithelial cells in the distal portion of the nephron. Expression of GLUT8 in the kidney was influenced by plasma glucose levels in vivo. Podocytes in kidneys of diabetic db/db mice express higher levels of GLUT8 compared to non-diabetic db/m mice. Since podocytes play an important role in glomerulosclerosis development and high levels of glucose have been shown to induce apoptotic cell death in various kidney cells, this data may provide further insight in the pathogenesis of glomerulosclerosis and diabetic nephropathy.
This article has been cited by other articles:
|
|
 |
|
  B. D. Schaan, U. F. Machado, S. Rogers, and D. J. Kelly Glucose transporters in animal models of diabetes and hypertension Am J Physiol Renal Physiol, September 1, 2006; 291(3): F702 - F703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Gomez, A. Romero, J. Terrado, and J. E Mesonero Differential expression of glucose transporter GLUT8 during mouse spermatogenesis Reproduction, January 1, 2006; 131(1): 63 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Linden, C. L. DeHaan, Y. Zhang, S. Glowacka, A. J. Cox, D. J. Kelly, and S. Rogers Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy Am J Physiol Renal Physiol, January 1, 2006; 290(1): F205 - F213. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
