AJP - Renal Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol (October 25, 2005). doi:10.1152/ajprenal.00240.2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
290/4/F797    most recent
00240.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kurtz, A.
Right arrow Articles by Schweda, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kurtz, A.
Right arrow Articles by Schweda, F.
Submitted on June 9, 2005
Accepted on October 17, 2005

OSMOLARITY INDUCED RENIN SECRETION FROM KIDNEYS- EVIDENCE FOR READILY RELEASABLE RENIN POOLS

Armin Kurtz1* and Frank Schweda1

1 Physiologisches Institut, Universitat Regensburg, Regensburg, Germany

* To whom correspondence should be addressed. E-mail: armin.kurtz{at}vkl.uni-regensburg.de.

Our study aimed to characterize the influence of changes of extracellular osmolarity on renin secretion from the whole kidney. For this purpose the osmolarity of the perfusion medium of isolated rat or mouse kidneys was either decreased by lowering the NaCl-concentration by 20% or was increased up to 133% by the addition of various salts or sugars. It turned out that changes of osmolarity led to instantaneous transient changes followed by a plateau of renin secretion, in the way that increases of osmolarity stimulated renin secretion, whilst decreases attenuated renin secretion. The peak amplitude of changes of renin secretion was related to steady state renin secretion rates prior to the osmotic challenge but was independent on the maneuver used to modulate steady state renin secretion. Osmolarity induced changes of renin secretion were more related to relative rather than to absolute changes of osmolarity and were not dependent on the formation of nitric oxide or of prostanoids and did not require Na-K-2Cl cotransport function or swelling activated chloride channels. Moreover, we obtained evidence, that the pool of renin secretion excitable by hyperosmolarity is exhaustible and that its complete refilling takes at least two minutes. The observed behavior of renin secretion fits into the concept about exocytosis proposing the existence of different pools of committed secretory vesicles, which have not yet undergone the final modification for initiation of exocytosis. Probably a pool of readily releasable vesicles determines steady state secretion rates from kidneys.




This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
U. G. Friis, K. Madsen, P. Svenningsen, P. B.L. Hansen, A. Gulaveerasingam, F. Jorgensen, C. Aalkjaer, O. Skott, and B. L. Jensen
Hypotonicity-Induced Renin Exocytosis from Juxtaglomerular Cells Requires Aquaporin-1 and Cyclooxygenase-2
J. Am. Soc. Nephrol., October 1, 2009; 20(10): 2154 - 2161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Bie, S. Molstrom, and S. Wamberg
Normotensive sodium loading in conscious dogs: regulation of renin secretion during {beta}-receptor blockade
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R428 - R435.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Matsumoto, Y. Inoue, T. Shimada, T. Matsunaga, and T. Aikawa
Stimulation of brain mast cells by compound 48/80, a histamine liberator, evokes renin and vasopressin release in dogs
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R689 - R698.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
F. Schweda, U. Friis, C. Wagner, O. Skott, and A. Kurtz
Renin Release
Physiology, October 1, 2007; 22(5): 310 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. H. Beierwaltes
A different vision of the osmolar regulation of renin secretion
Am J Physiol Renal Physiol, April 1, 2006; 290(4): F795 - F796.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1977 by the American Physiological Society.