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Am J Physiol Renal Physiol (March 25, 2003). doi:10.1152/ajprenal.00241.2002
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Submitted on July 3, 2002
Accepted on March 17, 2003

Phospholemman expression in extraglomerular mesangium and afferent arteriole of the juxtaglomerular apparatus

Randall K. Wetzel1 and Kathleen J. Sweadner1*

1 Laboratory of Membrane Biology, Massachusetts General Hospital, Charlestown, MA, USA

* To whom correspondence should be addressed. E-mail: sweadner{at}helix.mgh.harvard.edu.

The molecular mechanisms with which the juxtaglomerular apparatus accomplishes its twin functions, acute regulation of glomerular blood flow and secretion of renin, are still not clearly understood. Least understood is the role of the extraglomerular mesangial (EM) cells - also known as lacis or Goormaghtigh cells - which lie sandwiched between the macula densa and the afferent and efferent arterioles. Here we report that immunoreactivity for phospholemman (FXYD1), a single-span membrane protein homologous to the gamma ({gamma}) subunit of the Na,K-ATPase, is found in the kidney in EM cells with the Na,K-ATPase {beta}2 subunit, and in cortical blood vessels and the afferent arteriole with Na,K-ATPase {alpha}2 and {beta}2. Phospholemman's distribution in EM cells is distinct from that of the Na,K-ATPase {gamma} subunit, which is found on the basolateral surface of macula densa cells with Na,K-ATPase {alpha}1 and {beta}1. Phospholemman is a major kinase target, and its location in the juxtaglomerular apparatus suggests that it is involved in tubuloglomerular feedback.




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