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Articles in PresS, published online ahead of print November 19, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00258.2002
Submitted on July 18, 2002
Accepted on November 6, 2002
1 Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark
2 The Water and Salt Research Center, University of Aarhus, Aarhus, Denmark
3 Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
4 University Institute of Pathology, University of Aarhus, Aarhus, Denmark
* To whom correspondence should be addressed. E-mail: fitj{at}farmakol.ku.dk.
This study was designed to examine the effect of bilateral renal denervation (DNX) on thick ascending limb of Henles (TAL) function in rats with liver cirrhosis induced by common bile duct ligation (CBL). The CBL rats had, as previously shown, sodium retention associated with hypertrophy of the inner stripe of the outer medulla (ISOM), increased natriuretic effect of furosemide in vivo and semiquantitative immunoblotting showed increased expression of the furosemide sensitive Na-K-2Cl cotransporter (NKCC2) in ISOM from CBL rats. DNX significantly attenuated the sodium retention in the CBL rats, which was associated with normalization of the natriuretic effect of furosemide, as well as a significant reduction in the expression of NKCC2 in the ISOM. However, the marked hypertrophy of the ISOM found in CBL rats was not reversed by DNX. Together these data indicate that increased renal sympathetic nerve activity known to be present in CBL rats play a significant role for the formation of sodium retention by stimulating sodium reabsorption in the TAL via increased renal abundance of NKCC2.
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