| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print March 12, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00270.2001
Submitted on August 27, 2001
Accepted on March 2, 2002
1 Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
* To whom correspondence should be addressed. E-mail: robert.schrier{at}uchsc.edu.
ARF contributes substantially to the high morbidity and mortality observed during endotoxemia. We hypothesized that selective blockade of the renal nerves would be protective against ARF during the early (16hours) stage of endotoxemia (i.p. injection of lipopolysaccride (LPS) 5mg/kg in mice). At 16 h after LPS, there was no change in mean arterial pressure (MAP) but plasma epinephrine (4604±719 vs 490±152pg/ml, P<0.001), norepinephrine (2176±306 vs 1224±218pg/ml, p<0.05) and plasma renin activity (40±5 vs 27±2 ng/ml/hr, p<0.05) were higher in the LPS treated versus control mice. The high PRA level decreased to the control level with renal denervation in endotoxemic mice. After intravenous injection of phentolamine (200µg/kg), the decrement in MAP was significantly greater in LPS treated versus control mice (19.4±3.5 vs 8.1±1.5mmHg, P<0.01). 16h after LPS administration, there were significant decreases in GFR (52±18 vs 212±23µl/min, p<0.01) and RBF (0.58±0.08 vs 0.85±0.06ml/min, p<0.01) in sham operated mice. The decrement in GFR during endotoxemia was significantly attenuated in mice with denervated kidneys (32% vs 79%). Moreover, there was no change in RBF during endotoxemia in mice with renal denervation. The present results therefore demonstrate a protective role of renal denervation during normotensive endotoxemia-related ARF in mice, an effect which may be, at least in part, due to a diminished activation of the renin-angiotensin system.
This article has been cited by other articles:
|
|
 |
|
  W. Wang, S. Bansal, S. Falk, D. Ljubanovic, and R. Schrier Ghrelin protects mice against endotoxemia-induced acute kidney injury Am J Physiol Renal Physiol, October 1, 2009; 297(4): F1032 - F1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, E. Zolty, S. Falk, S. Summer, Z. Zhou, P. Gengaro, S. Faubel, N. Alp, K. Channon, and R. Schrier Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1 Am J Physiol Renal Physiol, March 1, 2008; 294(3): F571 - F576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. El-Achkar, Z. Plotkin, B. Marcic, and P. C. Dagher Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1187 - F1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, E. Zolty, S. Falk, S. Summer, R. Stearman, M. Geraci, and R. Schrier Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1131 - F1136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Zafar, Y. Tao, S. Falk, K. McFann, R. W. Schrier, and C. L. Edelstein Effect of statin and angiotensin-converting enzyme inhibition on structural and hemodynamic alterations in autosomal dominant polycystic kidney disease model Am J Physiol Renal Physiol, September 1, 2007; 293(3): F854 - F859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mitra, S. Bansal, W. Wang, S. Falk, E. Zolty, and R. W. Schrier Erythropoietin ameliorates renal dysfunction during endotoxaemia Nephrol. Dial. Transplant., August 1, 2007; 22(8): 2349 - 2353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.R. Lawrence, D. Raveh, B. Rudensky, and G. Munter Extreme leukocytosis in the emergency department QJM, April 1, 2007; 100(4): 217 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, E. Zolty, S. Falk, V. Basava, L. Reznikov, and R. Schrier Pentoxifylline protects against endotoxin-induced acute renal failure in mice Am J Physiol Renal Physiol, November 1, 2006; 291(5): F1090 - F1095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Poole, W. Wang, Y.-C. Chen, E. Zolty, S. Falk, A. Mitra, and R. Schrier Role of heme oxygenase-1 in endotoxemic acute renal failure Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1382 - F1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, S. Faubel, D. Ljubanovic, A. Mitra, S. A. Falk, J. Kim, Y. Tao, A. Soloviev, L. L. Reznikov, C. A. Dinarello, et al. Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice Am J Physiol Renal Physiol, May 1, 2005; 288(5): F997 - F1004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, A. Mitra, B. Poole, S. Falk, M. S. Lucia, S. Tayal, and R. Schrier Endothelial nitric oxide synthase-deficient mice exhibit increased susceptibility to endotoxin-induced acute renal failure Am J Physiol Renal Physiol, November 1, 2004; 287(5): F1044 - F1048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-J. Boffa, A. Just, T. M. Coffman, and W. J. Arendshorst Thromboxane Receptor Mediates Renal Vasoconstriction and Contributes to Acute Renal Failure in Endotoxemic Mice J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2358 - 2365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Schrier and W. Wang Acute Renal Failure and Sepsis N. Engl. J. Med., July 8, 2004; 351(2): 159 - 169. [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, S. Jittikanont, S. A. Falk, P. Li, L. Feng, P. E. Gengaro, B. D. Poole, R. P. Bowler, B. J. Day, J. D. Crapo, et al. Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure Am J Physiol Renal Physiol, March 1, 2003; 284(3): F532 - F537. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
