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Am J Physiol Renal Physiol (December 18, 2001). doi:10.1152/ajprenal.00279.2001
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Articles in PresS, published online ahead of print December 18, 2001
Am J Physiol Renal Physiol, 10.1152/ajprenal.00279.2001
Submitted on September 10, 2001
Accepted on December 10, 2001

Renal Nerve Stimulation Augments the Effect of Intraluminal Angiotensin II on Proximal Tubule Transport

Albert Quan1* and Michel Baum1

1 Pediatrics/Internal Medicine, UTSouthwestern Medical Center at Dallas, Dallas, TX, USA

* To whom correspondence should be addressed. E-mail: Albert.Quan{at}UTSouthwestern.edu.

The proximal tubule synthesizes and secretes angiotensin II into the lumen, where it regulates transport. Renal denervation abolishes the effect of angiotensin II on proximal tubule transport. Using in vivo microperfusion, we examined if renal nerve stimulation modulates the effect of angiotensin II on transport. The effect of angiotensin II was assessed by measuring the decrease in volume reabsorption with addition of 10-4M luminal enalaprilat. Luminal enalaprilat did not alter volume reabsorption in tubules with native innervation (2.80±0.18 vs. 2.34±0.14nl/mm.min). However, with renal nerve stimulation, luminal enalaprilat decreased volume reabsorption (3.45±0.22 vs. 1.67±0.20nl/mm.min, p<0.0005). The absolute/percent decrement in proximal tubule volume reabsorption observed with 10-4M luminal enalaprilat was higher with renal nerve stimulation than with native innervation (1.78±0.19 vs. 0.46±0.23nl/mm.min, p<0.02) and (51.8±5.0%vs.14.6±7.4%, p<0.05). Renal nerve stimulation did not alter the glomerular filtration rate or renal blood flow. Renal nerve stimulation augments the stimulatory effect of intraluminal angiotensin II on proximal tubule transport. The sympathetic renal nerves modulate the proximal tubule renin-angiotensin system and thereby regulate proximal tubule transport.




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