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1 Department of Physiology, College of Medicine, Chung-Shan Medical University, Taichung, United States
2 Cosmetic Science, Taichung Veterans General Hospital, United States
3 Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan - Republic of China
4 Biotechnology, Ming-Chuan University, United States
5 Medical Engineering, Ming-Chuan University, United States
6 Medicnie, Kao-Hsiung Medica University, United States
7 Obstetrics and Gynecology, Chung-Shan Medical University, United States
8 Institue of Veterinary Medicine, College of Veterinary Medicine, Chung-Hsing University, United States
9 Veternary Medicine, Chung-Hsing University, United States
10 Department of Physiology, College of Medicine, Chung-Shan Medical University, Tai-Chung, United States
* To whom correspondence should be addressed. E-mail: tblin{at}csmu.edu.tw.
The study was to investigate the pelvic nerve-to-external urethra sphincter (EUS) reflex potentiation can be induced under physiological conditions and to determine whether glutamatergic neurotransmission is involved in the reflex potentiation. Stimulation-evoked reflex activities, during rhythmic bladder contractions were recorded with/without the intrathecal administration of CNQX and APV. Reflex activities became potentiated following intravesical pressure (IVP) increase during the storage and the ascending period of the voiding phase. A post-voiding reflex potentiation in stimulation-evoked activities was elicited at the critical period after a voiding contraction had just finished. The slope of the regression line of evoked activities versus the IVP during the storage phase was significantly (p<0.01) higher than that of the ascending and descending periods of the voiding phase, but there was no statistical difference between the ascending and the descending periods (p>0.05). In addition, the slope of the regression line of post-tetanic reflex potentiation was significantly higher than that of the storage phase (p<0.01). All the slopes of the regression lines decreased after intrathecal CNQX administration in storage, ascending and descending period of the voiding phase, and post-voiding potentiation, respectively; all p<0.01, n=10). The slopes of the regression lines became almost horizontal after intrathecal APV administration in storage, ascending and descending period of voiding phase, and post-voiding potentiation, respectively; all p<0.01, n=10). Our results suggest that a potentiation in the pelvic nerve-to-EUS reflex can be induced under physiological conditions and the glutamatergic mechanism appears to be involved in this reflex potentiation.
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