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Articles in PresS, published online ahead of print January 28, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00306.2001
Submitted on September 28, 2001
Accepted on December 31, 2001
1 Department of Medicine, University of Maryland at Baltimore, Baltimore, MD, USA
Using nystatin perforated patch whole cell recording, we investigated the role of Cl- conductance in the modulation of outer medullary descending vasa recta (OMDVR) pericyte membrane potential (
m) by angiotensin II (AngII). AngII (10-11 to 10-7 M) consistently depolarized OMDVR and induced m oscillations at the lower concentrations. The Cl- channel blockers anthracene-9decarboxylate (A9C, 1 mM) and niflumic acid (10 µM) hyperpolarized resting pericytes and repolarized AngII treated pericytes. In voltage clamp experiments AngII treated pericytes exhibited slowly activating currents that were nearly eliminated by treatment with niflumic acid (10 µM) or removal of extracellular calcium. Those currents reversed at -31 mV and -10 mV when extracellular Cl- concentration was 152 and 34 mM, respectively. In pericytes held at -70 mV, oscillating inward currents were sometimes observed the reversal potential of which also shifted with extracellular Cl- concentration. We conclude that AngII activates a calcium dependent Cl- conductance in OMDVR pericytes to induce membrane depolarization and m oscillations.
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