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Articles in PresS, published online ahead of print March 18, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00309.2001
Submitted on October 3, 2001
Accepted on March 11, 2002
1 Division of nephrology, Geneva University Hospital, Geneva, Switzerland
* To whom correspondence should be addressed. E-mail: feraille{at}cmu.unige.ch.
Arginine vasopressin (AVP) plays a central role in water balance. In principal cells of the collecting system, AVP controls the expression of several genes, including aquaporin-2. Since nitric oxide (NO) participates in the regulation of water reabsorption by the collecting system, we analyzed the effect of AVP on the expression of nitric oxide synthase (NOS) isoforms in the kidney. Rats were either water-restricted or water-loaded to modify the circulating AVP levels and expressions of NOS isoforms were assessed by Western blot. In water-restricted rats, eNOS expression increased in the outer medulla and nNOS expression rose in both outer medulla and papilla. Conversely, water loading induced a decrease in expression of nNOS in outer medulla and papilla but did not alter eNOS expression. Oral administration of the specific V2 receptor antagonist, SR121463B, decreased nNOS expression in outer medulla and papilla but did not alter eNOS expression levels. Finally, the very low nNOS expression levels observed in AVP-deficient Brattleboro rats was restored by AVP infusion for one week. Thus, AVP specifically increases nNOS expression levels in renal outer medulla and papilla. Since nNOS is specifically expressed in principal cells of the collecting system, the stimulation of nNOS expression by AVP may participate in the control of water reabsorption.
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