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Articles in PresS, published online ahead of print January 28, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00310.2001
Submitted on October 3, 2001
Accepted on January 14, 2002
1 Departments of Urology and Medical Engineering, Kawasaki Medical School, Okayama, Japan
2 Department of Electrical Engineering, Okayama University of Science, Okayama, Japan
3 Department of Medicine, Physiology and Biophysics and Program in Bioengineering, State University of New York, Stony Brook, NY, USA
4 Department of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan
5 Department of Cardiovascular Physiology, Okayama University School of Medicine and Dentistry, Okayama, Japan
The recent refinement and computerization of intravital microscopy has permitted us to monitor microcirculation in vivo with minimal invasion. Here we report on the first findings made with the use of a pencil-lens intravital microscope as applied to ischemic rat kidney. Peritubular capillary and glomerular blood flow were monitored under basal conditions, during renal artery occlusion and immediately following release of the clamp. Erythrocyte velocity was calculated as an angle on consecutive spatio-temporal images. Intravital videomicroscopy during reperfusion period showed intermittent cessation and partial recovery of blood flow in both peritubular and glomerular capillaries. Blood flow was uniformly orthograde under control conditions, however, the retrograde flow occured upon reperfusion. The patency of peritubular capillaries was partially compromised during early reperfusion period, but rapidly recovered. The recovery of glomerular microcirculation occurred faster than that of peritubular capillaries. We suggest that a functional vasculopathy develops very early in the course of ischemia-reperfusion in superficial cortical microvasculature, and is more pronounced in peritubular capillaries, thus accounting for the development of patchy injury of tubular epithelia.
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