AJP - Renal Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol (July 2, 2002). doi:10.1152/ajprenal.00321.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/5/F995    most recent
00321.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ingert, C.
Right arrow Articles by Imbs, J.-L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ingert, C.
Right arrow Articles by Imbs, J.-L.

Articles in PresS, published online ahead of print July 2, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00321.2001
Submitted on October 26, 2001
Accepted on June 28, 2002

Effects of dietary salt changes on renal renin-angiotensin system in rats

Catherine Ingert1, Michele Grima2*, Catherine Coquard1, Mariette Barthelmebs1, and Jean-Louis Imbs2

1 Faculte de Medecine, Institut de Pharmacologie, Strasbourg, France
2 Faculte de Medecine, Institut de Pharmacologie, Strasbourg, France; Hopitaux Universitaires de Strasbourg, Service d'Hypertension, des maladies vasculaires et Pharmacologie clinique, Strasbourg, France

* To whom correspondence should be addressed. E-mail: michele.grima{at}pharmaco-ulp.u-strasbg.fr.

Renin (RA) and angiotensin-converting enzyme activities, angiotensinogen, angiotensin I (Ang I) and angiotensin II (Ang II) levels were measured in the kidney (cortex and medulla) and plasma of Wistar-Kyoto rats on a low-sodium diet (LS: 0.025% NaCl; n=8), a normal-sodium diet (NS: 1% NaCl; n=7) or a high-sodium diet (HS: 8% NaCl; n=7) for 21 days. RA, Ang I and Ang II levels increased in a manner inversely related to sodium content of the diet in both plasma and renal tissues. LS diet resulted in a 16-, 2.8- and 1.8-fold increase in plasma RA, Ang I and Ang II levels respectively compared to HS rats. In the renal cortex and medulla, RA, Ang I and Ang II levels were also increased by diminution of dietary salt content but, contrary to the plasma, Ang II levels increased much more than RA or Ang I levels (5.4- (cortex) and 4.7-fold (medulla) compared to HS rats). In summary, we demonstrated variations of Ang II levels in the kidney during salt diet modifications. Our results confirm that neither RA nor ACE activity are the steps limiting intrarenal Ang II levels. Nevertheless, despite RA and ACE activity differences between renal cortex and medulla, Ang I and Ang II levels are equivalent in these two tissues; these results argue against a compartmentalization of RAS in these two intrarenal areas.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. R. Carreno, L. L. Ji, and J. T. Cunningham
Altered central TRPV4 expression and lipid raft association related to inappropriate vasopressin secretion in cirrhotic rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R454 - R466.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. K. Sampson, K. M. Moritz, E. S. Jones, R. L. Flower, R. E. Widdop, and K. M. Denton
Enhanced Angiotensin II Type 2 Receptor Mechanisms Mediate Decreases in Arterial Pressure Attributable to Chronic Low-Dose Angiotensin II in Female Rats
Hypertension, October 1, 2008; 52(4): 666 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
I. Hamming, H. van Goor, A. J. Turner, C. A. Rushworth, A. A. Michaud, P. Corvol, and G. Navis
Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats
Exp Physiol, May 1, 2008; 93(5): 631 - 638.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Sakai, K. Tamura, Y. Tsurumi, Y. Tanaka, Y. Koide, M. Matsuda, T. Ishigami, M. Yabana, Y. Tokita, Y. Hiroi, et al.
Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression
Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1526 - F1536.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Sarr, M. Chataigneau, S. Martins, C. Schott, J. El Bedoui, M.-H. Oak, B. Muller, T. Chataigneau, and V. B. Schini-Kerth
Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: Role of NADPH oxidase
Cardiovasc Res, September 1, 2006; 71(4): 794 - 802.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. D. Pendergrass, D. B. Averill, C. M. Ferrario, D. I. Diz, and M. C. Chappell
Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2.Lewis rat
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1497 - F1506.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
U. C. Kopp, M. Z. Cicha, and L. A. Smith
Angiotensin blocks substance P release from renal sensory nerves by inhibiting PGE2-mediated activation of cAMP
Am J Physiol Renal Physiol, September 1, 2003; 285(3): F472 - F483.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Ingert, M. Grima, C. Coquard, M. Barthelmebs, and J.-L. Imbs
Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats
Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1003 - F1010.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.