AJP - Renal Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol (November 19, 2002). doi:10.1152/ajprenal.00338.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/3/F518    most recent
00338.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Castrop, H.
Right arrow Articles by Kurtz, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Castrop, H.
Right arrow Articles by Kurtz, A.

Articles in PresS, published online ahead of print November 19, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00338.2002
Submitted on September 19, 2002
Accepted on November 13, 2002

General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system

Hayo Castrop1, Jurgen Klar1, Charlotte Wagner1, Klaus Hocherl2, and Armin Kurtz1*

1 Department of Physiology, University of Regensburg, Regensburg, Germany
2 Department of Pharmacology, University of Regensburg, Regensburg, Germany

* To whom correspondence should be addressed. E-mail: armin.kurtz{at}vkl.uni-regensburg.de.

Since a board of data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel, and since angiotensin II can inhibit COX-2 expression, our study aimed to characterize a potential general inhibitory feedback of the renin-angiotensin system on renocortical COX-2 expression in vivo. Rats were fed either a high, a normal or a low salt diet or were chronically infused with furosemide (60 mg/kg/d) or the left renal artery was clipped, and the animals were treated in addition with or without the angiotensin converting enzyme (ACE) inhibitor ramipril (10 mg/kg/d). A high salt diet reduced expression of COX-2, whereas a low salt diet, furosemide infusion and renal artery stenosis stimulated COX-2 expression. Additional ACE-inhibition led to further increases in renocortical COX-2 expression by 62%, 136%, 300%, 50% and 70% for high, normal, low salt diet, furosemide infusion and renal artery stenosis, respectively. Thus, our data suggest a general inhibitory effect of the renin-angiotensin system on renocortical COX-2 expression.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Bachmann, K. Mutig, J. Bates, P. Welker, B. Geist, V. Gross, F. C. Luft, N. Alenina, M. Bader, B. J. Thiele, et al.
Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
Am J Physiol Renal Physiol, March 1, 2005; 288(3): F559 - F567.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
F. Schweda, M. Kammerl, C. Wagner, B. K. Kramer, and A. Kurtz
Upregulation of macula densa cyclooxygenase-2 expression is not dependent on glomerular filtration
Am J Physiol Renal Physiol, July 1, 2004; 287(1): F95 - F101.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.