| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Articles in PresS, published online ahead of print November 12, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00340.2002
Submitted on September 20, 2002
Accepted on November 11, 2002
1 Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA, USA
2 Department of Medicine, Duke University and Durham Veterans Affair Medical Centers, Durham, NC, USA
* To whom correspondence should be addressed. E-mail: lharris{at}tulane.edu.
The relative contributions of AT1A and AT1B receptors on afferent arteriole autoregulatory capability and afferent and efferent arteriole responses to angiotensin (Ang) II are not known. Experiments were conducted in kidneys from Wild-type (WT) and AT1A-/- mice utilizing the in vitro blood perfused juxtamedullary nephron technique. Direct measurements of afferent (AAD) and efferent arteriolar diameters (EAD) were assessed at a renal artery pressure (RAP) of 100mmHg. AAD averaged 14.8±0.8µm in WT and 14.9±0.8µm in AT1A-/- mice. AAD significantly decreased by 7±1, 16±1, and 26±2% in WT mice and by 11±1, 20±2, and 30±3% in AT1A-/- mice (120, 140, 160 mmHg). AAD autoregulatory capability was not affected by the absence of AT1A receptors. AAD responses to 10nM AngII were significantly blunted in AT1A-/- mice compared to WT (-22±2 vs -37±5%). AngII (0.1 to 10nM) failed to elicit any change in EAD in AT1A-/- mice. AAD and EAD reductions to AngII were blocked by 1µM Candesartan. We conclude that afferent arteriole vasoconstrictor responses to AngII are mediated by AT1A and AT1B receptors, while efferent arteriole vasoconstrictor responses to AngII are mediated by only AT1A receptors in the mouse kidney.
This article has been cited by other articles:
|
|
 |
|
  K. Machura, D. Steppan, B. Neubauer, N. Alenina, T. M. Coffman, C. S. Facemire, K. F. Hilgers, K.-U. Eckardt, C. Wagner, and A. Kurtz Developmental renin expression in mice with a defective renin-angiotensin system Am J Physiol Renal Physiol, November 1, 2009; 297(5): F1371 - F1380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Razga and J. R. Nyengaard Up- and down-regulation of angiotensin II AT1-A and AT1-B receptors in afferent and efferent rat kidney arterioles Journal of Renin-Angiotensin-Aldosterone System, December 1, 2008; 9(4): 196 - 201. [Abstract] [PDF]
|
|
|
|
|
|
S. Park, B. J. Bivona, Y. Feng, E. Lazartigues, and L. M. Harrison-Bernard Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1504 - F1511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Darlot, A. Artuso, N. Lautredou-Audouy, and D. Casellas Topology of Schwann cells and sympathetic innervation along preglomerular vessels: a confocal microscopic study in protein S100B/EGFP transgenic mice Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1142 - F1148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Park and L. M. Harrison-Bernard Augmented Renal Vascular nNOS and Renin Protein Expression in Angiotensin Type 1 Receptor Null Mice J. Histochem. Cytochem., April 1, 2008; 56(4): 401 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Park, B. J. Bivona, and L. M. Harrison-Bernard Compromised renal microvascular reactivity of angiotensin type 1 double null mice Am J Physiol Renal Physiol, July 1, 2007; 293(1): F60 - F67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Harrison-Bernard, C. J. Monjure, and B. J. Bivona Efferent arterioles exclusively express the subtype 1A angiotensin receptor: functional insights from genetic mouse models Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1177 - F1186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Ryan, S. P. Didion, S. Mathur, F. M. Faraci, and C. D. Sigmund Angiotensin II-Induced Vascular Dysfunction Is Mediated by the AT1A Receptor in Mice Hypertension, May 1, 2004; 43(5): 1074 - 1079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhou, W. P. Dirksen, G. J. Babu, and M. Periasamy Differential vasoconstrictions induced by angiotensin II: role of AT1 and AT2 receptors in isolated C57BL/6J mouse blood vessels Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2797 - H2803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhou, Y. Chen, W. P. Dirksen, M. Morris, and M. Periasamy AT1b Receptor Predominantly Mediates Contractions in Major Mouse Blood Vessels Circ. Res., November 28, 2003; 93(11): 1089 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. B. Helou, M. Imbert-Teboul, A. Doucet, R. Rajerison, C. Chollet, F. Alhenc-Gelas, and J. Marchetti Angiotensin receptor subtypes in thin and muscular juxtamedullary efferent arterioles of rat kidney Am J Physiol Renal Physiol, September 1, 2003; 285(3): F507 - F514. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
