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Articles in PresS, published online ahead of print February 5, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00358.2001
Submitted on December 7, 2001
Accepted on January 28, 2002
1 Department of Pediatrics, LSU Health Sciences Center, New Orleans, LA, USA
2 Laboratory of Kidney and Electrolyte Metabolism, NHLBI/NIH, Bethesda, MD, USA
* To whom correspondence should be addressed. E-mail: MVehaskari{at}pol.net.
Prenatal factors, especially intrauterine growth retardation, have been shown correlate with the risk of essential hypertension in adult life, but the mechanisms are unknown. An experimental model of prenatal programming of hypertension in the rat, induced by maternal low protein diet during pregnancy, was employed to study the role of renal Na reabsorption in the pathogenesis. The abundance of the apical Na transporters NHE3, BSC1, TSC, and ENaC was determined by semiquantitative immunoblotting in kidneys from the offspring at 4 weeks of age, before hypertension became manifest. There were no significant differences between the experimental and control rats in the abundance of NHE3 or any of the ENaC subunits. In contrast, the quantity of BSC1 in the experimental group was increased to 302% of control (P<0.001) and that of TSC to 157% of control (P<0.05). Determination of specific mRNA levels by ELISA-linked RT-PCR revealed a significantly increased BSC1 mRNA at age 1 day (P<0.01), 4 weeks (P<0.01), and 8 weeks (P<0.001), and a significantly increased TSC mRNA at age 4 weeks (P<0.05) in the experimental group. The results suggest that prenatal programming of hypertension involves transcriptional upregulation of Na transport in TAL and DCT.
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