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Am J Physiol Renal Physiol (July 24, 2002). doi:10.1152/ajprenal.00363.2001
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Articles in PresS, published online ahead of print July 24, 2002
Am J Physiol Renal Physiol, 10.1152/ajprenal.00363.2001
Submitted on December 13, 2001
Accepted on July 16, 2002

Decreased Renal Heme Oxygenase-1 Expression Contributes to Decreased Renal Function During Cirrhosis

Motoaki Miyazono1, Chrystelle Garat1, Kenneth G. Morris, Jr.1, and Ethan P. Carter1*

1 Cardiovascular-Pulmonary Research Laboratory and Departments of Medicine and Physiology & Biophysics, University of Colorado Health Sciences Center, Denver, CO, USA

* To whom correspondence should be addressed. E-mail: Ethan.Carter{at}uchsc.edu.

Heme oxygenase (HO) is the rate-limiting enzyme in the degradation of heme, catalyzing the oxidative cleavage of heme molecules to biliverdin, carbon monoxide, and iron. The current study was designed to investigate the role of HO-1 in the pathogenesis of renal dysfunction during cirrhosis. Biliary cirrhosis was induced in rats by common bile duct ligation (CBDL). Animals were studied 2 and 5 wk after surgery. In kidney from CBDL rats, HO-1 protein expression increased slightly at 2 wk, but was abolished at 5 wk. In addition, we confirmed histologically that HO-1 expression was suppressed in renal tubules and interlobular arterioles in 5-wk CBDL rats. Conversely, HO-1 expression in liver was strongly increased. Consistent with the development of cirrhosis and renal dysfunction mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were decreased in CBDL rats compared to sham-operated controls. In sham rats, treatment with the selective HO inhibitor zinc protoporphyrin (ZnPP) markedly decreased GFR and RBF to similar values measured in CBDL rats without decreasing MAP. In conclusion, decreased renal HO-1 expression contributes to deteriorated renal function and hemodynamics during cirrhosis. This finding provides a novel mechanism for the pathophysiology of renal dysfunction during cirrhosis.




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M. Miyazono, D. Zhu, R. Nemenoff, E. R. Jacobs, and E. P. Carter
Increased Epoxyeicosatrienoic Acid Formation in the Rat Kidney during Liver Cirrhosis
J. Am. Soc. Nephrol., July 1, 2003; 14(7): 1766 - 1775.
[Abstract] [Full Text] [PDF]


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