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Am J Physiol Renal Physiol (January 13, 2004). doi:10.1152/ajprenal.00384.2003
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Submitted on October 31, 2003
Accepted on January 8, 2004

EXPRESSION OF CLAUDINS 7 AND 8 ALONG THE MOUSE NEPHRON

Wing Y. Li1, Catherine L. Huey1, and Alan S.L. Yu1*

1 Division of Nephrology, Department of Medicine, and Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA, USA

* To whom correspondence should be addressed. E-mail: alanyu{at}usc.edu.

Claudins are integral membrane proteins of the tight junction that determine the magnitude and selectivity of paracellular permeability in epithelial tissues. The mammalian renal tubule exhibits considerable heterogeneity in the permeability properties of its different segments. To determine the nephron segment localization of claudins 7 and 8, immunofluorescence staining was performed on mouse kidney sections using isoform-specific antibodies. Claudin-8 was found to be expressed primarily at the tight junction along the entire aldosterone-sensitive distal nephron, and in the late segments of the thin descending limbs of long-looped nephrons. This pattern of expression is consistent with the putative role of claudin-8 as a paracellular cation barrier. By contrast, claudin-7 was found in the same nephron segments as claudin-8, but was expressed primarily at the basolateral membrane.




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