| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, USA
* To whom correspondence should be addressed. E-mail: dobriaad{at}evms.edu.
High salt diet is known to induce or aggravate hypertension in animal models of hypertension and humans. When Sprague-Dawley rats (n=60) are fed a moderately high fat diet (32kcal% fat, 0.8%NaCl) for 10 weeks, about half develop obesity (obesity-prone, OP) and mild hypertension, whereas the other half (obesity-resistant, OR) maintains body weight equivalent to a low fat control (C) and are normotensive. The aim of this study was to test the effect of high NaCl diets (2% and 4% NaCl) on the development of hypertension and obesity, oxidative stress and renal function. Both the 2% and 4% NaCl induced an early increase in systolic blood pressure of OP, but not OR or C rats. High salt intake induced an increase in the size and reduction in number of adipocytes, concomitant to a 2-fold increase in circulating leptin in OP rats. Aortic superoxide generation indicated a 2.8-fold increase in the OP-high salt vs. normal salt groups, while urine isoprostanes were not significantly increased. Also, hydroxynonenal protein adducts in the kidney were highly increased in OP rats on 2% and 4% NaCl, indicating oxidative stress in the renal tissue. Urine albumin was increased 3-fold in the OP on 2% NaCl and 4-fold in the same group on 4% NaCl vs. 0.8% NaCl. Kidney histology indicated a higher degree of glomerulosclerosis in OP rats on high salt diets. In summary, high salt diet accelerated the development, but did not increase the severity of hypertension; high salt increased oxidative stress in the vasculature and kidney and induced kidney glomerulosclerosis and microalbuminuria. Also, the OP rats on high salt displayed adipocyte hypertrophy and increased leptin production.
This article has been cited by other articles:
|
|
 |
|
  S. Tiwari, S. Riazi, and C. A. Ecelbarger Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes Am J Physiol Renal Physiol, October 1, 2007; 293(4): F974 - F984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Huang, C. Morisseau, J. Wang, T. Yang, J. R. Falck, B. D. Hammock, and M.-H. Wang Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats Am J Physiol Renal Physiol, July 1, 2007; 293(1): F342 - F349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y. Huang, K. M. Boini, H. Osswald, B. Friedrich, F. Artunc, S. Ullrich, J. Rajamanickam, M. Palmada, P. Wulff, D. Kuhl, et al. Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1264 - F1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Carroll, W. J. Zenebe, and T. B. Strange Cardiovascular Function in a Rat Model of Diet-Induced Obesity Hypertension, July 1, 2006; 48(1): 65 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. G. Krause, K. S. Curtis, T. L. Stincic, J. P. Markle, and R. J. Contreras Oestrogen and weight loss decrease isoproterenol-induced Fos immunoreactivity and angiotensin type 1 mRNA in the subfornical organ of female rats J. Physiol., May 15, 2006; 573(1): 251 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Agarwal, K. C. Nandipati, R. K. Sharma, C. D. Zippe, and R. Raina Role of Oxidative Stress in the Pathophysiological Mechanism of Erectile Dysfunction J Androl, May 1, 2006; 27(3): 335 - 347. [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. G. Magalhaes, A. B. da Silveira, D. L. Mota, and A. D. O. Paixao Renal function in juvenile rats subjected to prenatal malnutrition and chronic salt overload Exp Physiol, May 1, 2006; 91(3): 611 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Tallam, D. E. Stec, M. A. Willis, A. A. da Silva, and J. E. Hall Melanocortin-4 Receptor-Deficient Mice Are Not Hypertensive or Salt-Sensitive Despite Obesity, Hyperinsulinemia, and Hyperleptinemia Hypertension, August 1, 2005; 46(2): 326 - 332. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
