AJP - Renal Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol (May 18, 2004). doi:10.1152/ajprenal.00414.2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
287/3/F586    most recent
00414.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lovegrove, A. S.
Right arrow Articles by Lane, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lovegrove, A. S.
Right arrow Articles by Lane, P. H.
Submitted on November 26, 2003
Accepted on May 12, 2004

Estrogen Receptor {alpha} Mediated Events Promote Sex-Specific Diabetic Glomerular Hypertrophy

Alecia S. Lovegrove1, Jianhong Sun1, Karen A. Gould2, Dennis B. Lubahn3, Kenneth S. Korach4, and Pascale H. Lane1*

1 Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA
2 Eppley Research Institute, University of Nebraska Medical Center, Omaha, NE, USA
3 Department of Biochemistry and Child Health, University of Missouri, Columbia, MO, USA
4 National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA

* To whom correspondence should be addressed. E-mail: phlane{at}unmc.edu.

Sex differences in the incidence and progression of renal diseases suggest a protective role for estrogen. This study examined the role of estrogen receptor {alpha} (ER{alpha})-mediated events in normal and diabetic renal and glomerular growth. Wild-type and ER{alpha} null mice (ERKO) were observed over 2 weeks of streptozocin-induced diabetes. Blood glucose was monitored, and insulin given daily to maintain levels of 250-350 mg/dl. Body weight, kidney weight, glucose, insulin, renal transforming growth factor beta 1 (TGF{beta}1), and glomerular area (GA) were examined for effects of sex, genotype, and diabetes. Genotype had no effect on glomerular or renal size in male mice regardless of metabolic state. Nondiabetic female ERKO mice had kidney weights approaching those of wild-type males and much greater than those of wild-type females (0.15±0.04 vs. 0.11±0.04 gm; p<0.001). When only diabetic mice were studied, sex and/or genotype showed no effect on renal weight. Diabetic female ERKO mice had smaller GA than wild-types (2799±159 vs 3409±187 µm2; p=0.01). GA were similar in diabetic wild-type and ERKO males (3020±199 vs 3406±176 µm2). TGF{beta}1 levels, expressed as pg per mg total protein, were similar in diabetic wild-type and ERKO males (1.0±0.6 vs 0.9±0.6). In diabetic females, wild-types had significantly higher levels of this growth factor than ERKO mice (3.8±0.7 vs 1.1±0.6; p=0.005).. ER{alpha} mediated processes influence normal and diabetic renal and glomerular size, but only in female mice. These data do not support a protective role for ER{alpha}-mediated events in diabetic nephropathy.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
Q. Xu, A. Prabhu, S. Xu, M. B. Manigrasso, and C. Maric
Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidney
Am J Physiol Renal Physiol, August 1, 2009; 297(2): F307 - F315.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Maric
Sex, diabetes and the kidney
Am J Physiol Renal Physiol, April 1, 2009; 296(4): F680 - F688.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
C. Baylis
Sexual Dimorphism of the Aging Kidney: Role of Nitric Oxide Deficiency
Physiology, June 1, 2008; 23(3): 142 - 150.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
Q. Xu, C. C. Wells, J. H. Garman, L. Asico, C. S. Escano, and C. Maric
Imbalance in Sex Hormone Levels Exacerbates Diabetic Renal Disease
Hypertension, April 1, 2008; 51(4): 1218 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Sun, K. Devish, W. J. Langer, P. K. Carmines, and P. H. Lane
Testosterone treatment promotes tubular damage in experimental diabetes in prepubertal rats
Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1681 - F1690.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. C. Hoppe, R. G. Evans, J. F. Bertram, and K. M. Moritz
Effects of dietary protein restriction on nephron number in the mouse
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1768 - R1774.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. A. Carey, J. W. Card, J. A. Bradbury, M. P. Moorman, N. Haykal-Coates, S. H. Gavett, J. P. Graves, V. R. Walker, G. P. Flake, J. W. Voltz, et al.
Spontaneous Airway Hyperresponsiveness in Estrogen Receptor-{alpha}-deficient Mice
Am. J. Respir. Crit. Care Med., January 15, 2007; 175(2): 126 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Sun, W. J. Langer, K. Devish, and P. H. Lane
Compensatory kidney growth in estrogen receptor-{alpha} null mice
Am J Physiol Renal Physiol, February 1, 2006; 290(2): F319 - F323.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1977 by the American Physiological Society.