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Am J Physiol Renal Physiol (April 4, 2006). doi:10.1152/ajprenal.00453.2005
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Submitted on November 15, 2005
Accepted on March 16, 2006

Microbial nucleic acids pay a Toll in kidney disease

Rahul D Pawar1, Prashant S. Patole1, Markus Wornle1, and Hans-Joachim Anders1*

1 Medical Policlinic, University of Munich, Munich, Germany

* To whom correspondence should be addressed. E-mail: hjanders{at}med.uni-muenchen.de.

Nucleic acids provide more than the genetic code that determines the morphological and functional phenotype of microbes and eucarionts. In fact, nucleic acids have immunomodulatory functions as they are recognized by a set of pattern-recognition receptors that initite and modulate immune responses in the host. Toll-like receptor (TLR)-3 recognizes double-stranded RNA, TLR7 and TLR8 recognize single-stranded RNA, CpG-DNA is a ligand for TLR9, and all of these TLRs are expressed in the nephritic kidney. In this review we summarize recent advances in this field and discuss new hypotheses for the pathogenesis of kidney diseases that are triggered by infectious organisms.




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J. R. Faulhaber and P. J. Nelson
Virus-Induced Cellular Immune Mechanisms of Injury to the Kidney
Clin. J. Am. Soc. Nephrol., July 1, 2007; 2(Supplement_1): S2 - S5.
[Abstract] [Full Text] [PDF]


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